Kunitz-type peptides of the sea anemone Heteractis crispa: Potential anti-inflammatory compounds

被引：0

作者：

O. V. Sintsova

E. A. Pislyagin

I. N. Gladkikh

M. M. Monastyrnaya

E. S. Menchinskaya

E. V. Leychenko

D. L. Aminin

E. P. Kozlovskaya

机构：

[1] Russian Academy of Sciences,G.B. Elyakov Pacific Institute of Bioorganic Chemistry Far Eastern Branch

[2] Far Eastern Federal University,School of Natural Sciences

来源：

Russian Journal of Bioorganic Chemistry | 2017年 / 43卷

关键词：

sea anemone; Kunitz-type protease inhibitors; antihistamine activity;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Antihistamine activity of recombinant peptides, Kunitz-type serine protease inhibitors of the sea anemone Heteractis crispa, was studied. It was shown that the peptides rHCGS1.19 and rHCGS1.36 at a concentration 10 μM inhibit an increase in the calcium ion concentration in macrophages elicited by histamine at 62.2 and 84.0%, respectively. The anti-inflammatory effect can be seen as the result of mediated reactions between peptides and proteases involved in these processes, as with the histamine H1-type receptor blocking.

引用

页码：91 / 97

页数：6

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