Kunitz-type peptides of the sea anemone Heteractis crispa: Potential anti-inflammatory compounds

被引：0
|
作者：
O. V. Sintsova
E. A. Pislyagin
I. N. Gladkikh
M. M. Monastyrnaya
E. S. Menchinskaya
E. V. Leychenko
D. L. Aminin
E. P. Kozlovskaya
机构：
[1] Russian Academy of Sciences,G.B. Elyakov Pacific Institute of Bioorganic Chemistry Far Eastern Branch
[2] Far Eastern Federal University,School of Natural Sciences
来源：
Russian Journal of Bioorganic Chemistry | 2017年 / 43卷
关键词：
sea anemone; Kunitz-type protease inhibitors; antihistamine activity;
D O I：
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学科分类号：
摘要：
Antihistamine activity of recombinant peptides, Kunitz-type serine protease inhibitors of the sea anemone Heteractis crispa, was studied. It was shown that the peptides rHCGS1.19 and rHCGS1.36 at a concentration 10 μM inhibit an increase in the calcium ion concentration in macrophages elicited by histamine at 62.2 and 84.0%, respectively. The anti-inflammatory effect can be seen as the result of mediated reactions between peptides and proteases involved in these processes, as with the histamine H1-type receptor blocking.
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页码：91 / 97
页数：6
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