Gender differences in cholinergic and dopaminergic deficits in Parkinson disease

被引：0

作者：

Vikas Kotagal

Roger L. Albin

Martijn L. T. M. Müller

Robert A. Koeppe

Kirk A. Frey

Nicolaas I. Bohnen

机构：

[1] University of Michigan,Department of Neurology

[2] Neurology Service and GRECC,Division of Nuclear Medicine, Department of Radiology

[3] VAAAHS,undefined

[4] University of Michigan,undefined

来源：

Journal of Neural Transmission | 2013年 / 120卷

关键词：

Gender; Women; Acetylcholine; Dopamine; Parkinson disease;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

As Parkinson disease (PD) may affect men and women differentially, we investigated gender differences in regional projection system integrity in 148 PD subjects (36 women, 112 men) using monoaminergic [11C]dihydrotetrabenazine and acetylcholinesterase [11C]PMP positron emission tomography. After controlling for age, disease duration, and Hoehn and Yahr score, men showed 5.9 % greater caudate dopaminergic denervation (p = 0.0018) and 5.8 % greater neocortical cholinergic denervation (p = 0.0097). No significant gender differences were seen in putaminal dopaminergic or thalamic cholinergic denervation.

引用

页码：1421 / 1424

页数：3

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