Gender differences in cholinergic and dopaminergic deficits in Parkinson disease

被引：0

作者：

Vikas Kotagal

Roger L. Albin

Martijn L. T. M. Müller

Robert A. Koeppe

Kirk A. Frey

Nicolaas I. Bohnen

机构：

[1] University of Michigan,Department of Neurology

[2] Neurology Service and GRECC,Division of Nuclear Medicine, Department of Radiology

[3] VAAAHS,undefined

[4] University of Michigan,undefined

来源：

Journal of Neural Transmission | 2013年 / 120卷

关键词：

Gender; Women; Acetylcholine; Dopamine; Parkinson disease;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

As Parkinson disease (PD) may affect men and women differentially, we investigated gender differences in regional projection system integrity in 148 PD subjects (36 women, 112 men) using monoaminergic [11C]dihydrotetrabenazine and acetylcholinesterase [11C]PMP positron emission tomography. After controlling for age, disease duration, and Hoehn and Yahr score, men showed 5.9 % greater caudate dopaminergic denervation (p = 0.0018) and 5.8 % greater neocortical cholinergic denervation (p = 0.0097). No significant gender differences were seen in putaminal dopaminergic or thalamic cholinergic denervation.

引用

页码：1421 / 1424

页数：3

共 50 条

[31] Cognitive Executive Impairment and Dopaminergic Deficits in De Novo Parkinson's Disease
Siepel, Francoise J.
Bronnick, Kolbjorn S.
Booij, Jan
Ravina, Bernard M.
Lebedev, Alexander V.
Pereira, Joana B.
Gruner, Renate
Aarsland, Dag
MOVEMENT DISORDERS, 2014, 29 (14) : 1802 - 1808
[32] Cholinergic deficits contribute to impaired postural control in early Parkinson's disease
Yarnall, A. J.
Del Din, S.
David, R.
Galna, B.
Baker, M. R.
Burn, D. J.
Rochester, L.
MOVEMENT DISORDERS, 2014, 29 : S332 - S333
[33] White Matter Lesions Are a More Robust Determinant of Cognitive Impairment Than Nigrostriatal Dopaminergic or Cortical Cholinergic Deficits in Parkinson Disease without Dementia
Bohnen, Nicolaas
Muller, Martijn
Zarzhevsky, Natalia
Albin, Roger
Frey, Kirk
NEUROLOGY, 2011, 76 (09) : A262 - A262
[34] Role of pedunculopontine cholinergic neurons in the vulnerability of nigral dopaminergic neurons in Parkinson's disease
Bensaid, Manale
Michel, Patrick P.
Clark, Stewart D.
Hirsch, Etienne C.
Francois, Chantal
EXPERIMENTAL NEUROLOGY, 2016, 275 : 209 - 219
[35] Ratings of "Mental Rigidity" Reflect Cholinergic Rather Than Dopaminergic Denervation in Parkinson Disease
Chou, Kelvin L.
Muller, Martijn L.
Koeppe, Robert A.
Kilbourn, Michael R.
Frey, Kirk A.
Albin, Roger L.
Bohnen, Nicolaas I.
NEUROLOGY, 2010, 74 (09) : A84 - A84
[36] Cholinergic brain network deficits associated with vestibular sensory conflict deficits in Parkinson’s disease: correlation with postural and gait deficits
Nicolaas I. Bohnen
Prabesh Kanel
Stiven Roytman
Peter J. H. Scott
Robert A. Koeppe
Roger L. Albin
Kevin A. Kerber
Martijn L. T. M. Müller
Journal of Neural Transmission, 2022, 129 : 1001 - 1009
[37] Cholinergic brain network deficits associated with vestibular sensory conflict deficits in Parkinson's disease: correlation with postural and gait deficits
Bohnen, Nicolaas, I
Kanel, Prabesh
Roytman, Stiven
Scott, Peter J. H.
Koeppe, Robert A.
Albin, Roger L.
Kerber, Kevin A.
Muller, Martijn L. T. M.
JOURNAL OF NEURAL TRANSMISSION, 2022, 129 (08) : 1001 - 1009
[38] CHOLINERGIC BRAIN NETWORK DEFICITS ASSOCIATED WITH VESTIBULAR SENSORY CONFLICT DEFICITS IN PARKINSON'S DISEASE: CORRELATION WITH POSTURAL AND GAIT DEFICITS
Bohnen, N.
Kanel, P.
Scott, P.
Koeppe, R.
Boas, M. van Emde
Albin, R.
Kerber, K.
Muller, M.
PARKINSONISM & RELATED DISORDERS, 2023, 113 : 15 - 16
[39] Gender differences in Parkinson's disease symptom profile
Scott, B
Borgman, A
Engler, H
Johnels, B
Aquilonius, SM
ACTA NEUROLOGICA SCANDINAVICA, 2000, 102 (01): : 37 - 43
[40] Gender differences in Parkinson's disease: A clinical perspective
Georgiev, D.
Hamberg, K.
Hariz, M.
Forsgren, L.
Hariz, G. -M.
ACTA NEUROLOGICA SCANDINAVICA, 2017, 136 (06): : 570 - 584

← 1 2 3 4 5 →