Gender differences in cholinergic and dopaminergic deficits in Parkinson disease

被引：0
|
作者：
Vikas Kotagal
Roger L. Albin
Martijn L. T. M. Müller
Robert A. Koeppe
Kirk A. Frey
Nicolaas I. Bohnen
机构：
[1] University of Michigan,Department of Neurology
[2] Neurology Service and GRECC,Division of Nuclear Medicine, Department of Radiology
[3] VAAAHS,undefined
[4] University of Michigan,undefined
来源：
Journal of Neural Transmission | 2013年 / 120卷
关键词：
Gender; Women; Acetylcholine; Dopamine; Parkinson disease;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
As Parkinson disease (PD) may affect men and women differentially, we investigated gender differences in regional projection system integrity in 148 PD subjects (36 women, 112 men) using monoaminergic [11C]dihydrotetrabenazine and acetylcholinesterase [11C]PMP positron emission tomography. After controlling for age, disease duration, and Hoehn and Yahr score, men showed 5.9 % greater caudate dopaminergic denervation (p = 0.0018) and 5.8 % greater neocortical cholinergic denervation (p = 0.0097). No significant gender differences were seen in putaminal dopaminergic or thalamic cholinergic denervation.
引用
收藏
页码：1421 / 1424
页数：3
相关论文
共 50 条
  • [1] Gender differences in cholinergic and dopaminergic deficits in Parkinson disease
    Kotagal, Vikas
    Albin, Roger L.
    Mueller, Martijn L. T. M.
    Koeppe, Robert A.
    Frey, Kirk A.
    Bohnen, Nicolaas I.
    JOURNAL OF NEURAL TRANSMISSION, 2013, 120 (10) : 1421 - 1424
  • [2] Gender Differences in Dopaminergic and Cholinergic Integrity in Parkinson Disease
    Kotagal, Vikas
    Albin, Roger
    Muller, Martijn
    Koeppe, Robert
    Gilman, Sid
    Frey, Kirk
    Bohnen, Nicolaas
    NEUROLOGY, 2013, 80
  • [3] Cholinergic Deficits in Parkinson Disease
    Miller, R.
    Dhavale, D.
    O'Shea, J.
    Franklin, E.
    Cairns, N.
    Perrin, R.
    Campbell, M.
    Perlmutter, J.
    Kotzbauer, P.
    MOVEMENT DISORDERS, 2023, 38 : S656 - S656
  • [4] Dopaminergic, serotonergic, and noradrenergic deficits in Parkinson disease
    Buddhala, Chandana
    Loftin, Susan K.
    Kuley, Brandon M.
    Cairns, Nigel J.
    Campbell, Meghan C.
    Perlmutter, Joel S.
    Kotzbauer, Paul T.
    ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY, 2015, 2 (10): : 949 - 959
  • [5] Cholinergic and dopaminergic PET imaging of gait in Parkinson disease
    Muller, Martijn
    Albin, Roger
    Koeppe, Robert
    Kilbourn, Michael
    Frey, Kirk
    Bohnen, Nicolaas
    JOURNAL OF NUCLEAR MEDICINE, 2010, 51
  • [6] Ipsilateral deficits of dopaminergic neurotransmission in Parkinson's disease
    Kaasinen, Valtteri
    ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY, 2016, 3 (01): : 21 - 26
  • [7] Dementia in Parkinson disease - Functional imaging of cholinergic and dopaminergic pathways
    Hilker, R
    Thomas, AV
    Klein, JC
    Weisenbach, S
    Kalbe, E
    Burghaus, L
    Jacobs, AH
    Herholz, K
    Heiss, WD
    NEUROLOGY, 2005, 65 (11) : 1716 - 1722
  • [8] Understanding the dopaminergic deficits in Parkinson's disease: Insights into disease heterogeneity
    Lewis, Simon J. G.
    Barker, Roger A.
    JOURNAL OF CLINICAL NEUROSCIENCE, 2009, 16 (05) : 620 - 625
  • [9] Frequency of Cholinergic and Caudate Nucleus Dopaminergic Deficits Across the Predemented Cognitive Spectrum of Parkinson Disease and Evidence of Interaction Effects
    Bohnen, Nicolaas I.
    Albin, Roger L.
    Mueller, Martijn L. T. M.
    Petrou, Myria
    Kotagal, Vikas
    Koeppe, Robert A.
    Scott, Peter J. H.
    Frey, Kirk A.
    JAMA NEUROLOGY, 2015, 72 (02) : 194 - 200
  • [10] Deficits in cholinergic neurotransmission and their clinical correlates in Parkinson’s disease
    Perez-Lloret S.
    Barrantes F.J.
    npj Parkinson's Disease, 2 (1)
12345