New synthesis of 3,3-disubstituted piperidin-2-ones from esters and 1-(3-halopropyl)-2,5-dimethylpyrroles

被引：0
|
作者：
V. D. Gvozdev
K. N. Shavrin
O. M. Nefedov
机构：
[1] Russian Academy of Sciences,N. D. Zelinsky Institute of Organic Chemistry
来源：
Russian Chemical Bulletin | 2019年 / 68卷
关键词：
piperidin-2-ones; esters; alkylation; protection groups; 2,5-dimethylpyrrole protection; cyclization;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
3,3-Disubstituted piperidin-2-ones were obtained by alkylation of carboxylic acid esters with 1-(3-halopropyl)-2,5-dimethylpyrroles using lithium diisopropylamide as a base followed by the removal of 2,5-dimethylpyrrole protection and intramolecular cyclization. The overall yields of the target products amounted to 78% in two synthetic steps.
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页码：2108 / 2113
页数：5
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