New synthesis of 3,3-disubstituted piperidin-2-ones from esters and 1-(3-halopropyl)-2,5-dimethylpyrroles

被引：0

作者：

V. D. Gvozdev

K. N. Shavrin

O. M. Nefedov

机构：

[1] Russian Academy of Sciences,N. D. Zelinsky Institute of Organic Chemistry

来源：

Russian Chemical Bulletin | 2019年 / 68卷

关键词：

piperidin-2-ones; esters; alkylation; protection groups; 2,5-dimethylpyrrole protection; cyclization;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

3,3-Disubstituted piperidin-2-ones were obtained by alkylation of carboxylic acid esters with 1-(3-halopropyl)-2,5-dimethylpyrroles using lithium diisopropylamide as a base followed by the removal of 2,5-dimethylpyrrole protection and intramolecular cyclization. The overall yields of the target products amounted to 78% in two synthetic steps.

引用

页码：2108 / 2113

页数：5

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