Human Aurora-B binds to a proteasome α-subunit HC8 and undergoes degradation in a proteasome-dependent manner

被引：0
|
作者：
Fengjue Shu
Shuguang Guo
Yongjun Dang
Meiyan Qi
Guangjin Zhou
Zekun Guo
Ying Zhang
Chaoqun Wu
Shouyuan Zhao
Long Yu
机构：
[1] Fudan University,State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science
来源：
Molecular and Cellular Biochemistry | 2003年 / 254卷
关键词：
Aurora-B; degradation; HC8; mitosis; proteasome;
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学科分类号：
摘要：
Human Aurora/Ipl1-related kinase 2 (Aurora-B) is a key regulator of mitosis. Here human proteasome α-subunit C8 (HC8) was identified to interact with the Aurora-B by yeast two-hybrid screen. This finding was confirmed by GST pull-down assays and immunoprecipitation experiments. The Aurora-B protein level increased in HeLa cells cultured with proteasome inhibitor ALLN. Our data suggest that Aurora-B might undergo degradation by binding to HC8 in a proteasome-dependent manner during mitosis.
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页码：157 / 162
页数：5
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