The peripheral sympathetic nervous system is the major target of cannabinoids in eliciting cardiovascular depression

被引：0

作者：

Nathalie Niederhoffer

Karin Schmid

Bela Szabo

机构：

[1] Institut für Experimentelle und Klinische Pharmakologie und Toxikologie,

来源：

Naunyn-Schmiedeberg's Archives of Pharmacology | 2003年 / 367卷

关键词：

Anaesthetised rat; Blood pressure; Cannabinoid receptor; Heart rate; Pithed rat; Plasma noradrenaline; Respiration; Sympathetic regulation;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Our objective was to identify the sites of interaction of cannabinoids with cardiovascular sympathetic regulation in the rat. Effects on sympathetic tone were first determined in anaesthetised animals following i.v. administration of the drugs. Central effects were evaluated in anaesthetised rats receiving microinjections of cannabinoids into brain stem nuclei. Peripheral effects were identified in pithed rats with electrically stimulated sympathetic outflow.

引用

页码：434 / 443

页数：9

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