Sympathetic nervous system as a target for aging and obesity-related cardiovascular diseases

被引：62

作者：

Balasubramanian, Priya ^{[1
]}

Hall, Delton ^{[2
]}

Subramanian, Madhan ^{[2
]}

机构：

[1] Univ Oklahoma, Hlth Sci Ctr, Reynolds Oklahoma Ctr Aging, Oklahoma City, OK 73104 USA

[2] Oklahoma State Univ, Ctr Vet Hlth Sci, Dept Physiol Sci, 277 McElroy Hall, Stillwater, OK 74078 USA

来源：

GEROSCIENCE | 2019年 / 41卷 / 01期

关键词：

Obesity; Aging; Hypertension; Sympathetic nerve activity; Inflammation; Leptin; Renin-angiotensin system; Oxidative stress; Cellular senescence; ROSTRAL VENTROLATERAL MEDULLA; SELECTIVE LEPTIN RESISTANCE; CELLULAR SENESCENCE; BLOOD-PRESSURE; OXIDATIVE STRESS; ARTERIAL-PRESSURE; RENAL DENERVATION; ADIPOSE-TISSUE; HYPERTENSION; AGE;

D O I：

10.1007/s11357-018-0048-5

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Chronic sympathetic nervous system overactivity is a hallmark of aging and obesity and contributes to the development of cardiovascular diseases including hypertension and heart failure. The cause of this chronic sympathoexcitation in aging and obesity is multifactorial and centrally mediated. In this mini-review, we have provided an overview of the key and emerging central mechanisms contributing to the pathogenesis of sympathoexcitation in obesity and healthy aging, specifically focusing on hypertension. A clear understanding of these mechanisms will pave way for targeting the sympathetic nervous system for the treatment of cardiovascular diseases in obesity and aging.

引用

页码：13 / 24

页数：12

共 50 条

[1] Sympathetic nervous system as a target for aging and obesity-related cardiovascular diseases
Priya Balasubramanian
Delton Hall
Madhan Subramanian
[J]. GeroScience, 2019, 41 : 13 - 24
[2] The role of the sympathetic nervous system in obesity-related hypertension
Alexandre A. da Silva
Jussara do Carmo
John Dubinion
John E. Hall
[J]. Current Hypertension Reports, 2009, 11
[3] The role of the sympathetic nervous system in obesity-related hypertension
da Silva, Alexandre A.
do Carmo, Jussara
Dubinion, John
Hall, John E.
[J]. CURRENT HYPERTENSION REPORTS, 2009, 11 (03) : 206 - 211
[4] Sympathetic nervous system in obesity-related hypertension: mechanisms and clinical implications
Kalil, Graziela Z.
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[J]. HYPERTENSION RESEARCH, 2012, 35 (01) : 4 - 16
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[J]. CURRENT HYPERTENSION REPORTS, 2002, 4 (02) : 112 - 118
[7] Sympathetic nervous system in obesity-related hypertension: mechanisms and clinical implications
Graziela Z Kalil
William G Haynes
[J]. Hypertension Research, 2012, 35 : 4 - 16
[8] PATHOPHYSIOLOGY OF OBESITY-RELATED HYPERTENSION - ROLE OF INSULIN AND THE SYMPATHETIC NERVOUS-SYSTEM
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[J]. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1994, 23 : S1 - S8
[9] Sympathetic nervous system: Contribution to human hypertension and related cardiovascular diseases
Esler, M
[J]. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1995, 26 : S24 - S28
[10] THE SYMPATHETIC NERVOUS-SYSTEM AS A TARGET FOR INTERVENTION IN OBESITY
ASTRUP, A
[J]. INTERNATIONAL JOURNAL OF OBESITY, 1995, 19 : S24 - S28

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