Sympathetic nervous system as a target for aging and obesity-related cardiovascular diseases

被引：0

作者：

Priya Balasubramanian

Delton Hall

Madhan Subramanian

机构：

[1] University of Oklahoma Health Sciences Center,Reynolds Oklahoma Center on Aging

[2] Oklahoma State University,Department of Physiological Sciences, Center for Veterinary Health Sciences

来源：

GeroScience | 2019年 / 41卷

关键词：

Obesity; Aging; Hypertension; Sympathetic nerve activity; Inflammation; Leptin; Renin-angiotensin system; Oxidative stress; Cellular senescence;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Chronic sympathetic nervous system overactivity is a hallmark of aging and obesity and contributes to the development of cardiovascular diseases including hypertension and heart failure. The cause of this chronic sympathoexcitation in aging and obesity is multifactorial and centrally mediated. In this mini-review, we have provided an overview of the key and emerging central mechanisms contributing to the pathogenesis of sympathoexcitation in obesity and healthy aging, specifically focusing on hypertension. A clear understanding of these mechanisms will pave way for targeting the sympathetic nervous system for the treatment of cardiovascular diseases in obesity and aging.

引用

页码：13 / 24

页数：11

共 50 条

[1] Sympathetic nervous system as a target for aging and obesity-related cardiovascular diseases
Balasubramanian, Priya
Hall, Delton
Subramanian, Madhan
[J]. GEROSCIENCE, 2019, 41 (01) : 13 - 24
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[10] THE SYMPATHETIC NERVOUS-SYSTEM AS A TARGET FOR INTERVENTION IN OBESITY
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