The long isoform uncoupling protein-3 (UCP3L) in human energy homeostasis

被引：0

作者：

WK Chung

A Luke

RS Cooper

C Rotini

A Vidal-Puig

M Rosenbaum

D Gordon

SM Leal

S Caprio

R Goldsmith

AL Andreu

C Bruno

S DiMauro

M Heo

WL Lowe

BB Lowell

DB Allison

RL Leibel

机构：

[1] Columbia University,Departments of Pediatrics and Medicine, Division of Molecular Genetics

[2] College of Physicians and Surgeons,Department of Preventive Medicine and Epidemiology

[3] Naomi Berrie Diabetes Center,Division of Endocrinology

[4] Russ Berrie Medical Science Pavilion,Division of Pediatric Endocrinology

[5] Loyola University Medical Center,Department of Medicine

[6] Beth Israel-Deaconess Medical Center,undefined

[7] The Rockefeller University,undefined

[8] Yale University School of Medicine,undefined

[9] St Luke’s / Roosevelt Hospital Center,undefined

[10] Obesity Research Center,undefined

[11] Columbia University College of Physicians and Surgeons,undefined

[12] Northwestern University School of Medicine,undefined

[13] Columbia University College of Physicians & Surgeons,undefined

[14] H. Houston Merritt Clinical Research Centre for Muscular Dystrophy and Related Diseases,undefined

来源：

International Journal of Obesity | 1999年 / 23卷

关键词：

obesity; diabetes; skeletal muscle; thermogenesis;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The biological role(s) proposed for UCP3 in energy homeostasis have been based primarily upon amino acid sequence homology to UCP1. Spontaneous mutations of UCP3 have been described in humans, but not in rodents. The functional consequences—or lack thereof—of these mutations in humans will be of great importance in elucidating the biology of this protein. The results of two such studies are summarized here.

引用

页码：S49 / S50

共 50 条

[41] Mitochondrial import of the long and short isoforms of human uncoupling protein 3
Renold, A
Koehler, CM
Murphy, MP
FEBS LETTERS, 2000, 465 (2-3) : 135 - 140
[42] Variations in the uncoupling protein-3 gene are associated with specific obesity phenotypes
van Abeelen, Annet F. M.
de Krom, Mariken
Hendriks, Judith
Grobbee, Diederick E.
Adan, Roger A. H.
van der Schouw, Yvonne T.
EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2008, 158 (05) : 669 - 676
[43] Uncoupling protein 3 (UCP3) variants associated to severe childhood obesity: involvement of UCP3 in long chain fatty acid oxidation and in the prevention of triglyceride storage
Musa, C., V
Mancini, A.
Alfieri, A.
Labruna, G.
Valerio, G.
Franzese, A.
Pasanisi, F.
Licenziati, M. R.
Sachetti, L.
Buono, P.
DIABETES OBESITY & METABOLISM, 2010, 12 : 39 - 40
[44] Uncoupling Protein (UCP3) Plays an Important Role in Ischemic Preconditioning
Ozcan, Cevher
Palmeri, Monica
Russell, Raymond R., III
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2009, 53 (10) : A311 - A311
[45] The human uncoupling protein-3 gene promoter requires MyoD and is induced by retinoic acid in muscle cells
Solanes, G
Pedraza, N
Iglesias, R
Giralt, M
Villarroya, F
FASEB JOURNAL, 2000, 14 (14): : 2141 - 2143
[46] Chronic low-frequency stimulation (CLFS) up-regulates mitochondrial (mt) uncoupling protein-3 (UCP-3) in rat tibialis anterior (TA)
Putman, CT
O'Brien, CL
Kiricsi, MA
Leisner, E
Pette, D
FASEB JOURNAL, 2002, 16 (04): : A445 - A445
[47] Regulation of uncoupling protein-2 and uncoupling protein-3 mRNA expression during lipid infusion in human skeletal muscle and subcutaneous adipose tissue
Khalfallah, Y
Fages, S
Laville, M
Langin, D
Vidal, H
DIABETES, 2000, 49 (01) : 25 - 31
[48] Effect of ultrasonic stimulation on mRNA abundance of uncoupling protein (UCP) 2 and UCP 3 in gastrocnemius muscle of rats
Kogure, A
Yoshida, T
Takakura, Y
Umekawa, T
Hioki, C
Yoshioka, K
Yoshimoto, K
Yoshikawa, T
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2005, 32 (1-2) : 91 - 93
[49] Uncoupling protein-3 expression in skeletal muscle and free fatty acids in obesity
Boss, O
Bobbioni-Harsch, E
Assimacopoulos-Jeannet, F
Muzzin, P
Munger, R
Giacobino, JP
Golay, A
LANCET, 1998, 351 (9120): : 1933 - 1933
[50] UNCOUPLING PROTEIN-3 MEDIATES THE LOSS OF MITOCHONDRIAL MEMBRANE POTENTIAL IN SEVERE SEPSIS
Zolfaghari, P.
Singer, M.
Duchen, M. R.
INTENSIVE CARE MEDICINE, 2009, 35 : 164 - 164

← 1 2 3 4 5 →