The long isoform uncoupling protein-3 (UCP3L) in human energy homeostasis

被引：0

作者：

WK Chung

A Luke

RS Cooper

C Rotini

A Vidal-Puig

M Rosenbaum

D Gordon

SM Leal

S Caprio

R Goldsmith

AL Andreu

C Bruno

S DiMauro

M Heo

WL Lowe

BB Lowell

DB Allison

RL Leibel

机构：

[1] Columbia University,Departments of Pediatrics and Medicine, Division of Molecular Genetics

[2] College of Physicians and Surgeons,Department of Preventive Medicine and Epidemiology

[3] Naomi Berrie Diabetes Center,Division of Endocrinology

[4] Russ Berrie Medical Science Pavilion,Division of Pediatric Endocrinology

[5] Loyola University Medical Center,Department of Medicine

[6] Beth Israel-Deaconess Medical Center,undefined

[7] The Rockefeller University,undefined

[8] Yale University School of Medicine,undefined

[9] St Luke’s / Roosevelt Hospital Center,undefined

[10] Obesity Research Center,undefined

[11] Columbia University College of Physicians and Surgeons,undefined

[12] Northwestern University School of Medicine,undefined

[13] Columbia University College of Physicians & Surgeons,undefined

[14] H. Houston Merritt Clinical Research Centre for Muscular Dystrophy and Related Diseases,undefined

来源：

International Journal of Obesity | 1999年 / 23卷

关键词：

obesity; diabetes; skeletal muscle; thermogenesis;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The biological role(s) proposed for UCP3 in energy homeostasis have been based primarily upon amino acid sequence homology to UCP1. Spontaneous mutations of UCP3 have been described in humans, but not in rodents. The functional consequences—or lack thereof—of these mutations in humans will be of great importance in elucidating the biology of this protein. The results of two such studies are summarized here.

引用

页码：S49 / S50

共 50 条

[31] Uncoupling protein-2/uncoupling protein-3 gene polymorphism is not associated with anorexia nervosa
Ando, T
Kodama, N
Ishikawa, T
Naruo, T
Tachikawa, N
Nozaki, T
Okabe, K
Takeuchi, K
Masuda, A
Kawamura, N
Komaki, G
PSYCHIATRIC GENETICS, 2004, 14 (04) : 215 - 218
[32] The human uncoupling protein-3 gene - Genomic structure, chromosomal localization, and genetic basis for short and long form transcripts
Solanes, G
VidalPuig, A
Grujic, D
Flier, JS
Lowell, BB
JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (41) : 25433 - 25436
[33] Uncoupling of protein-3 induces an uncontrolled uncoupling of mitochondria after expression in muscle derived L6 cells
Guerini, D
Prati, E
Desai, U
Nick, HP
Flammer, R
Grüninger, S
Cumin, F
Kaleko, M
Connelly, S
Chiesi, M
EUROPEAN JOURNAL OF BIOCHEMISTRY, 2002, 269 (05): : 1373 - 1381
[34] Skeletal muscle mitoflashes, pH, and the role of uncoupling protein-3
McBride, S.
Wei-LaPierre, L.
McMurray, F.
MacFarlane, M.
Qiu, X.
Patten, D. A.
Dirksen, R. T.
Harper, M. -E.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2019, 663 : 239 - 248
[35] The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP
Ricquier, D
Bouillaud, F
BIOCHEMICAL JOURNAL, 2000, 345 : 161 - 179
[36] Uncoupling Protein 3 (UCP3) but Not UCP2 Gene Expression Is Increased in the Human Glucose Transporter - 4 Overexpressing Suckling Mice
N K MacLennan
C D Hart
R H Lane
S U Devaskar
Pediatric Research, 1999, 45 : 56 - 56
[37] Uncoupling protein 3 (UCP3) but not UCP2 gene expression is increased in the human glucose transporter - 4 overexpressing suckling mice
MacLennan, NK
Hart, CD
Lane, RH
Devaskar, SU
PEDIATRIC RESEARCH, 1999, 45 (04) : 56A - 56A
[38] Impaired expression of the uncoupling protein-3 gene in skeletal muscle during lactation -: Fibrates and troglitazone reverse lactation-induced downregulation of the uncoupling protein-3 gene
Pedraza, N
Solanes, G
Carmona, MC
Iglesias, R
Viñas, O
Mampel, T
Vazquez, M
Giralt, M
Villarroya, F
DIABETES, 2000, 49 (07) : 1224 - 1230
[39] Uncoupling protein-3 (UCP3) mRNA expression in reconstituted human muscle after myoblast transplantation in RAG2-/-/γc/C5- immunodeficient mice
Guigal, N
Rodriguez, M
Cooper, RN
Dromaint, S
Di Santo, JP
Mouly, V
Boutin, JA
Galizzi, JP
JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (49) : 47407 - 47411
[40] Uncoupling protein 3 and physical activity: the role of uncoupling protein 3 in energy metabolism revisited
Schrauwen, P
Hesselink, M
PROCEEDINGS OF THE NUTRITION SOCIETY, 2003, 62 (03) : 635 - 643

← 1 2 3 4 5 →