Potential antimalarial derivatives from astraodorol

被引：0
|
作者：
Pitak Nasomjai
Kittibhorn Arpha
Sirirath Sodngam
Simon D. Brandt
机构：
[1] Khon Kaen University,Natural Products Research Unit, Centre of Excellence for Innovation in Chemistry, Department of Chemistry, Faculty of Science
[2] Liverpool John Moores University,School of Pharmacy and Biomolecular Sciences
来源：
Archives of Pharmacal Research | 2014年 / 37卷
关键词：
Lanostane-type triterpenes; Astraodorol; Antimalarial; Cytotoxicity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Astraodorol, a major lanostane-type triterpene isolated from the edible mushroom Astraeus odoratus, was subjected to chemical modifications. Ten derivatives have been synthesized and their biological activities were evaluated. Compounds 5, 6, 7a, 7c, 7e, 7f, and 7 g exhibited strong antimalarial activity with IC50 values of 4.85, 4.48, 4.16, 4.46, 3.45, 3.23, and 3.41 µg/mL, respectively. Compounds 7a, 7c, and 7e showed moderate cytotoxicity against NCI-H187 with IC50 values of 23.36, 34.28, and 9.84 µg/mL. Compound 7e demonstrated moderate cytotoxicity against KB, MCF-7, and Vero cell lines with IC50 values of 16.94, 49.60, and 26.48 µg/mL, respectively.
引用
收藏
页码：1538 / 1545
页数：7
相关论文
共 50 条
  • [41] From mechanistic studies on artemisinin derivatives to new modular antimalarial drugs
    Robert, A
    Dechy-Cabaret, O
    Cazelles, J
    Meunier, B
    ACCOUNTS OF CHEMICAL RESEARCH, 2002, 35 (03) : 167 - 174
  • [42] New antimalarial and cytotoxic sungucine derivatives from Strychnos icaja roots
    Frédérich, M
    De Pauw, MC
    Llabrès, G
    Tits, M
    Hayette, MP
    Brandt, V
    Penelle, J
    De Mol, P
    Angenot, L
    PLANTA MEDICA, 2000, 66 (03) : 262 - 269
  • [43] Antimalarial Activity of Piperidine Alkaloids from Senna spectabilis and Semisynthetic Derivatives
    Pivatto, Marcos
    Baccini, Luciene R.
    Sharma, Abhinay
    Nakabashi, Myna
    Danuello, Amanda
    Viegas Junior, Claudio
    Garcia, Celia R. S.
    Bolzani, Vanderlan S.
    JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, 2014, 25 (10) : 1900 - +
  • [44] Potential antimalarial lead structures from fungi of marine origin
    Wright, AD
    Lang-Unnasch, N
    PLANTA MEDICA, 2005, 71 (10) : 964 - 966
  • [45] Antimalarial Agents from Plants: Neocryptolepine Derivatives and Standardised Extracts from Traditional Medicine
    Pieters, L.
    PLANTA MEDICA, 2009, 75 (04) : 402 - 402
  • [46] Synthesis and antimalarial activity of febrifugine derivatives
    Takeuchi, Y
    Koike, M
    Azuma, K
    Nishioka, H
    Abe, H
    Kim, HS
    Wataya, Y
    Harayama, T
    CHEMICAL & PHARMACEUTICAL BULLETIN, 2001, 49 (06) : 721 - 725
  • [47] Antimalarial activity of unsaturated putrescine derivatives
    Slater, LA
    McMonagle, FA
    Phillips, RS
    Robins, DJ
    ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY, 1998, 92 (03): : 271 - 277
  • [48] Synthesis and antimalarial activity of trioxaquine derivatives
    Dechy-Cabaret, O
    Benoit-Vical, F
    Loup, C
    Robert, A
    Gornitzka, H
    Bonhoure, A
    Vial, H
    Magnaval, JF
    Séguéla, JP
    Meunier, B
    CHEMISTRY-A EUROPEAN JOURNAL, 2004, 10 (07) : 1625 - 1636
  • [49] Antimalarial activity and cytotoxicity of zerumbone derivatives
    Sriphana, Uraiwan
    Pitchuanchom, Siripit
    Kongsaeree, Palangpon
    Yenjai, Chavi
    SCIENCEASIA, 2013, 39 (01): : 95 - 99
  • [50] Antimalarial activity of new acridinone derivatives
    Fernandez-Calienes, Ayme
    Pellon, Rolando
    Docampo, Maite
    Fascio, Mirta
    D'Accorso, Norma
    Maes, Louis
    Mendiola, Judith
    Monzote, Lianet
    Gille, Lars
    Rojas, Lazara
    BIOMEDICINE & PHARMACOTHERAPY, 2011, 65 (03) : 210 - 214
12345