Potential antimalarial derivatives from astraodorol

被引：0
|
作者：
Pitak Nasomjai
Kittibhorn Arpha
Sirirath Sodngam
Simon D. Brandt
机构：
[1] Khon Kaen University,Natural Products Research Unit, Centre of Excellence for Innovation in Chemistry, Department of Chemistry, Faculty of Science
[2] Liverpool John Moores University,School of Pharmacy and Biomolecular Sciences
来源：
Archives of Pharmacal Research | 2014年 / 37卷
关键词：
Lanostane-type triterpenes; Astraodorol; Antimalarial; Cytotoxicity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Astraodorol, a major lanostane-type triterpene isolated from the edible mushroom Astraeus odoratus, was subjected to chemical modifications. Ten derivatives have been synthesized and their biological activities were evaluated. Compounds 5, 6, 7a, 7c, 7e, 7f, and 7 g exhibited strong antimalarial activity with IC50 values of 4.85, 4.48, 4.16, 4.46, 3.45, 3.23, and 3.41 µg/mL, respectively. Compounds 7a, 7c, and 7e showed moderate cytotoxicity against NCI-H187 with IC50 values of 23.36, 34.28, and 9.84 µg/mL. Compound 7e demonstrated moderate cytotoxicity against KB, MCF-7, and Vero cell lines with IC50 values of 16.94, 49.60, and 26.48 µg/mL, respectively.
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页码：1538 / 1545
页数：7
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