Structure and assembly of the NOT module of the human CCR4–NOT complex

被引:0
|
作者
Andreas Boland
Ying Chen
Tobias Raisch
Stefanie Jonas
Duygu Kuzuoğlu-Öztürk
Lara Wohlbold
Oliver Weichenrieder
Elisa Izaurralde
机构
[1] Max Planck Institute for Developmental Biology,Department of Biochemistry
来源
Nature Structural & Molecular Biology | 2013年 / 20卷
关键词
D O I
暂无
中图分类号
学科分类号
摘要
The CCR4–NOT deadenylase complex has a crucial role in post-transcriptional mRNA regulation, catalyzing the removal of mRNA poly(A) tails and consequently repressing translation and promoting mRNA degradation. The crystal structure of the human NOT module, formed by the CNOT1, CNOT2 and CNOT3 C-terminal regions, now provides a structural framework for understanding its assembly and functions.
引用
收藏
页码:1289 / 1297
页数:8
相关论文
共 50 条
  • [41] Role of the chemokine receptors CXCR3 and CCR4 in human pulmonary fibrosis
    Pignatti, P
    Brunetti, G
    Moretto, D
    Yacoub, MR
    Fiori, M
    Balbi, B
    Balestrino, A
    Cervio, G
    Nava, S
    Moscato, G
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2006, 173 (03) : 310 - 317
  • [42] A complex containing the CCR4 and CAF1 proteins is involved in mRNA deadenylation in Drosophila
    Temme, C
    Zaessinger, S
    Meyer, S
    Simonelig, M
    Wahle, E
    EMBO JOURNAL, 2004, 23 (14): : 2862 - 2871
  • [43] RNA deadenylation by CCR4–NOT controls heart function
    Alexandra Le Bras
    Nature Reviews Cardiology, 2018, 15 : 197 - 197
  • [44] The NOT proteins are part of the CCR4 transcriptional complex and affect gene expression both positively and negatively
    Liu, HY
    Badarinarayana, V
    Audino, DC
    Rappsilber, J
    Mann, M
    Denis, CL
    EMBO JOURNAL, 1998, 17 (04): : 1096 - 1106
  • [45] Discovery and SAR of trisubstituted thiazolidinones as CCR4 antagonists
    Allen, S
    Newhouse, B
    Anderson, AS
    Fauber, B
    Allen, A
    Chantry, D
    Eberhardt, C
    Odingo, J
    Burgess, LE
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14 (07) : 1619 - 1624
  • [46] Trametinib improves Treg selectivity of α-CCR4 mAb by regulating CCR4 expression in CTLs induced via TCR/TGF-β signaling
    Ono, Shoya
    Suzuki, Susumu
    Kondo, Yutaro
    Goto, Mitsuo
    Ogawa, Tetsuya
    Ito, Hideaki
    Takahara, Taishi
    Satou, Akira
    Tsuzuki, Toyonori
    Yoshikawa, Kazuhiro
    Nagao, Toru
    Ueda, Ryuzo
    CANCER SCIENCE, 2023, 114 : 2062 - 2062
  • [47] CCR4 is a key modulator of innate immune responses
    Ness, Traci L.
    Ewing, Jillian L.
    Hogaboam, Cory M.
    Kunkel, Steven L.
    JOURNAL OF IMMUNOLOGY, 2006, 177 (11): : 7531 - 7539
  • [48] Paradoxical Increase in Skin Inflammation in the Absence of CCR4
    Sells, Ryan E.
    Hwang, Sam T.
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2010, 130 (12) : 2697 - 2699
  • [49] CC Chemokine Receptor 4 (CCR4) in human allergen-induced late nasal responses
    Banfield, G.
    Watanabe, H.
    Scadding, G.
    Jacobson, M. R.
    Till, S. J.
    Hall, D. A.
    Robinson, D. S.
    Lloyd, C. M.
    Nouri-Aria, K. T.
    Durham, S. R.
    ALLERGY, 2010, 65 (09) : 1126 - 1133
  • [50] Trametinib improves Treg selectivity of α-CCR4 mAb by regulating CCR4 expression in CTLs induced via TCR/TGF-β signaling
    Ono, Shoya
    Suzuki, Susumu
    Kondo, Yutaro
    Goto, Mitsuo
    Ogawa, Tetsuya
    Ito, Hideaki
    Takahara, Taishi
    Satou, Akira
    Tsuzuki, Toyonori
    Yoshikawa, Kazuhiro
    Nagao, Toru
    Ueda, Ryuzo
    CANCER SCIENCE, 2023, 114 : 1631 - 1631