Structure and assembly of the NOT module of the human CCR4–NOT complex

被引：0
|
作者：
Andreas Boland
Ying Chen
Tobias Raisch
Stefanie Jonas
Duygu Kuzuoğlu-Öztürk
Lara Wohlbold
Oliver Weichenrieder
Elisa Izaurralde
机构：
[1] Max Planck Institute for Developmental Biology,Department of Biochemistry
来源：
Nature Structural & Molecular Biology | 2013年 / 20卷
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摘要：
The CCR4–NOT deadenylase complex has a crucial role in post-transcriptional mRNA regulation, catalyzing the removal of mRNA poly(A) tails and consequently repressing translation and promoting mRNA degradation. The crystal structure of the human NOT module, formed by the CNOT1, CNOT2 and CNOT3 C-terminal regions, now provides a structural framework for understanding its assembly and functions.
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页码：1289 / 1297
页数：8
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