Replication stress activates DNA repair synthesis in mitosis

被引：0
|
作者：
Sheroy Minocherhomji
Songmin Ying
Victoria A. Bjerregaard
Sara Bursomanno
Aiste Aleliunaite
Wei Wu
Hocine W. Mankouri
Huahao Shen
Ying Liu
Ian D. Hickson
机构：
[1] Center for Chromosome Stability and Center for Healthy Aging,Department of Cellular and Molecular Medicine
[2] University of Copenhagen,Department of Respiratory and Critical Care Medicine of the Second Affiliated Hospital
[3] Panum Institute,Department of Pharmacology
[4] Zhejiang University School of Medicine,undefined
[5] Zhejiang University School of Medicine,undefined
[6] State Key Laboratory of Respiratory Disease (SKLRD),undefined
来源：
Nature | 2015年 / 528卷
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摘要：
Common fragile sites (CFSs) are difficult-to-replicate regions of eukaryotic genomes that are sensitive to replication stress and that require resolution by the MUS81–EME1 endonuclease to re-initiate POLD3-dependent DNA synthesis in early mitosis; this study defines the specific pathway of events causing the CFS fragility phenotype.
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页码：286 / 290
页数：4
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