Replication stress activates DNA repair synthesis in mitosis

被引：0

作者：

Sheroy Minocherhomji

Songmin Ying

Victoria A. Bjerregaard

Sara Bursomanno

Aiste Aleliunaite

Wei Wu

Hocine W. Mankouri

Huahao Shen

Ying Liu

Ian D. Hickson

机构：

[1] Center for Chromosome Stability and Center for Healthy Aging,Department of Cellular and Molecular Medicine

[2] University of Copenhagen,Department of Respiratory and Critical Care Medicine of the Second Affiliated Hospital

[3] Panum Institute,Department of Pharmacology

[4] Zhejiang University School of Medicine,undefined

[5] Zhejiang University School of Medicine,undefined

[6] State Key Laboratory of Respiratory Disease (SKLRD),undefined

来源：

Nature | 2015年 / 528卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Common fragile sites (CFSs) are difficult-to-replicate regions of eukaryotic genomes that are sensitive to replication stress and that require resolution by the MUS81–EME1 endonuclease to re-initiate POLD3-dependent DNA synthesis in early mitosis; this study defines the specific pathway of events causing the CFS fragility phenotype.

引用

页码：286 / 290

页数：4

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