Association of distal chromosome 2q with IDDM in Japanese subjects

被引:0
|
作者
J. Fu
H. Ikegami
Y. Kawaguchi
T. Fujisawa
Y. Kawabata
Y. Hamada
H. Ueda
M. Shintani
K. Nojima
N. Babaya
Q.-J. Shen
Y. Uchigata
T. Urakami
Y. Omori
K. Shima
T. Ogihara
机构
[1] Department of Geriatric Medicine,
[2] Osaka University Medical School,undefined
[3] Osaka,undefined
[4] Japan,undefined
[5] Diabetes Center,undefined
[6] Tokyo Women's Medical College,undefined
[7] Tokyo,undefined
[8] Japan,undefined
[9] Department of Pediatrics,undefined
[10] Nihon University School of Medicine,undefined
[11] Tokyo,undefined
[12] Japan,undefined
[13] Department of Laboratory Medicine,undefined
[14] Tokushima University School of Medicine,undefined
[15] Tokushima,undefined
[16] Japan,undefined
来源
Diabetologia | 1998年 / 41卷
关键词
Keywords Genetic susceptibility; linkage disequilibrium; association; positional cloning; microsatellite marker.;
D O I
暂无
中图分类号
学科分类号
摘要
An insulin-dependent diabetes mellitus (IDDM)-susceptibility gene (IDDM13) has recently been mapped to a region of distal chromosome 2q, which is syntenic to the region of mouse chromosome 1 containing a murine susceptibility gene for IDDM, Idd5. To determine the contribution of this region to IDDM disease susceptibility further and to narrow the region for positional cloning of susceptibility genes, we have studied the association of distal chromosome 2q with IDDM in the genetically distinct Japanese population. A 137 mobility unit (mu) allele at D2S137 locus was significantly associated with IDDM (odds ratio 1.92, p = 0.0016). Other markers, D2S301 and D2S143, located in the same region were not associated with IDDM, indicating that IDDM13 is in linkage disequilibrium with D2S137, but not with D2S301 or D2S143. The association of D2S137 with IDDM was observed in patients lacking one of two high risk HLA alleles, DQB1*0303 and DQB1*0401, but not in patients with either of these alleles. The frequency of high risk HLA alleles was significantly lower in patients with the susceptible allele at D2S137, suggesting that IDDM13 contributes to IDDM susceptibility in subjects without high risk genotypes at IDDM1. Demonstration of allelic association of D2S137 with IDDM localizes IDDM13 in the close vicinity (< 2 centiMorgans) of D2S137, greatly facilitating fine structure mapping and positional cloning of IDDM13. [Diabetologia (1998) 41: 228–232]
引用
收藏
页码:228 / 232
页数:4
相关论文
共 50 条
  • [1] Association of distal chromosome 2q with IDDM in Japanese subjects
    Fu, J
    Ikegami, H
    Kawaguchi, Y
    Fujisawa, T
    Kawabata, Y
    Hamada, Y
    Ueda, H
    Shintani, M
    Nojima, K
    Babaya, N
    Shen, QJ
    Uchigata, Y
    Urakami, T
    Omori, Y
    Shima, K
    Ogihara, T
    [J]. DIABETOLOGIA, 1998, 41 (02) : 228 - 232
  • [2] Associations of distal chromosome 2q with type 1 diabetes in Japanese subjects
    Nishino, M
    Ikegami, H
    Kawaguchi, Y
    Fujisawa, T
    Hotta, M
    Ueda, H
    Shintani, M
    Nojima, K
    Kawabata, Y
    Ono, M
    Yamada, K
    Itoi, M
    Taniguchi, H
    Noso, S
    Babaya, N
    Fu, J
    Ogihara, T
    [J]. DIABETES MELLITUS: RECENT ADVANCES FOR THE 21ST CENTURY, 2000, 1209 : 99 - 102
  • [3] GENETIC SUSCEPTIBILITY TO IDDM - CHROMOSOME 6P VERSUS CHROMOSOME 2Q
    POCIOT, F
    BERGHOLDT, R
    JOHANNESEN, J
    NERUP, J
    [J]. DIABETOLOGIA, 1994, 37 : A6 - A6
  • [4] Evidence of association for a susceptibility region for autism on chromosome 2q
    Conroy, J
    Segurado, R
    Meally, E
    Stallings, R
    Green, A
    Fitzgerald, M
    Gill, M
    Ennis, S
    Gallagher, L
    [J]. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2004, 130B (01): : 21 - 21
  • [5] Association of two loci on chromosome 2q with nodal osteoarthritis
    Wright, GD
    Hughes, AE
    Regan, M
    Doherty, M
    [J]. ANNALS OF THE RHEUMATIC DISEASES, 1996, 55 (05) : 317 - 319
  • [6] ASSOCIATION OF 2 LOCI ON CHROMOSOME 2Q WITH NODAL OSTEOARTHRITIS (NOA)
    WRIGHT, GD
    HUGHES, AE
    REGAN, M
    DOHERTY, M
    [J]. ARTHRITIS AND RHEUMATISM, 1995, 38 (09): : 43 - 43
  • [7] REGIONAL MAPPING OF LOCI FROM HUMAN-CHROMOSOME 2Q TO SHEEP CHROMOSOME 2Q
    ANSARI, HA
    PEARCE, PD
    MAHER, DW
    MALCOLM, AA
    WOOD, NJ
    PHUA, SH
    BROAD, TE
    [J]. GENOMICS, 1994, 20 (01) : 122 - 124
  • [8] Family association studies of markers on chromosome 2q and Type 1 diabetes in subjects from South India
    Ogunkolade, WB
    Ramachandran, A
    McDermott, MF
    Kumarajeewa, TR
    Curtis, D
    Snehalatha, C
    Mohan, V
    Cassell, PG
    Eskdale, J
    Gallagher, G
    Hitman, GA
    [J]. DIABETES-METABOLISM RESEARCH AND REVIEWS, 2000, 16 (04) : 276 - 280
  • [9] Markers on distal chromosome 2q linked to insulin-dependent diabetes mellitus
    Morahan, G
    Huang, DX
    Tait, BD
    Colman, PG
    Harrison, LC
    [J]. SCIENCE, 1996, 272 (5269) : 1811 - 1813
  • [10] ATOPIC-DERMATITIS AND CHROMOSOME 2Q
    COLEMAN, R
    PERIAN, N
    OLEY, C
    HARPER, J
    TREMBATH, R
    [J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1994, 103 (03) : 437 - 437