Association of two loci on chromosome 2q with nodal osteoarthritis

被引:63
|
作者
Wright, GD
Hughes, AE
Regan, M
Doherty, M
机构
[1] BELFAST CITY HOSP,DEPT MED GENET,BELFAST BT9 7AD,ANTRIM,NORTH IRELAND
[2] CITY HOSP NOTTINGHAM,DEPT RHEUMATOL,NOTTINGHAM,ENGLAND
关键词
D O I
10.1136/ard.55.5.317
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective-To search for genetic association between microsatellite marker loci and sibling pairs with nodal osteoarthritis (NOA). Methods-Using the affected sibling pair method of analysis, genomic DNA from 66 sib pairs with NOA was analysed for association with highly polymorphic microsatellite marker loci. The microsatellite markers were amplified using polymerase chain reaction and typed on polyacrylamide gels. Results-A significant association (p < 0.05) was identified between NOA and two loci on the short arm of chromosome 2 (2q 23-35). Candidate genes for osteoarthritis in this region include: fibronectin, a glycoprotein present in the extracellular matrix of normal cartilage; the alpha 2 chain of collagen type V, a major constituent of bone; and the interleukin-8 receptor, important in the regulation of neutrophil activation and chemotaxis. Conclusions-The chromosomal region 2q 23-35 requires further detailed study in NOA. Confirmation of these findings in large independent data sets and further analysis of candidate genes in this region will be important in unravelling the molecular basis for this common disease.
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收藏
页码:317 / 319
页数:3
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