Tetra-substituted pyrazole analogues: synthesis, molecular docking, ADMET prediction, antioxidant and pancreatic lipase inhibitory activities

被引：0
|
作者：
Adnan Cetin
Ali Donmez
Abdullah Dalar
Ishak Bildirici
机构：
[1] Van Yuzuncu Yil University,Department of Chemistry, Faculty of Education
[2] Van Yuzuncu Yil University,Department of Pharmaceutical Chemistry, Faculty of Pharmacy
[3] Van Yuzuncu Yil University,Department of Pharmaceutical Botany, Faculty of Pharmacy
来源：
Medicinal Chemistry Research | 2023年 / 32卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Synthesis, characterization and biological properties of tetra-substituted pyrazole analogues.Discovery of tetra-substituted pyrazole analogues as potential Pancreatic lipase enzyme inhibitor.Molecular docking studies of the tetra-substituted pyrazole analogues.A molecular approach in drug development for obesity disease.
引用
收藏
页码：189 / 204
页数：15
相关论文
共 50 条
  • [31] Synthesis, structural investigation of Schiff base endowed organyltellurium(IV) complexes: biological activities, molecular docking, quantum chemical computations and ADMET prediction
    Dalal, Mahak
    Dubey, Amit
    Antil, Nidhi
    Tufail, Aisha
    Garg, Sapana
    RESEARCH ON CHEMICAL INTERMEDIATES, 2023, 49 (07) : 2889 - 2917
  • [32] The free, esterified, and insoluble-bound phenolic profiles of Rhus chinensis Mill. fruits and their pancreatic lipase inhibitory activities with molecular docking analysis
    Zhang, Chengting
    Ma, Yanli
    Gao, Fanding
    Zhao, Yingxin
    Cai, Shengbao
    Pang, Mingjie
    JOURNAL OF FUNCTIONAL FOODS, 2018, 40 : 729 - 735
  • [33] Synthesis, antibacterial activity, in silico ADMET prediction, docking, and molecular dynamics studies of substituted phenyl and furan ring containing thiazole Schiff base derivatives
    Islam, Md. Din
    Saha, Joyanta Kumar
    Marufa, Sumita Saznin
    Kundu, Tanmoy Kumar
    Hossain, Ismail
    Nishino, Hiroshi
    Alam, Mohammad Sayed
    Haque, Md. Aminul
    Rahman, Mohammad Mostafizur
    PLOS ONE, 2025, 20 (03):
  • [34] Glutathione Peroxidase-like Antioxidant Activity of 1,3-Benzoselenazoles: Synthesis and In Silico Molecular Docking Studies as Pancreatic Lipase Inhibitors
    Yadav, Manisha
    Singh, Vijay P.
    JOURNAL OF ORGANIC CHEMISTRY, 2023, 88 (24): : 16934 - 16948
  • [35] ZnO Nanoparticle-Assisted Synthesis of Thiazolo[3,2-α]Pyrimidine Analogs: Antibacterial and Antioxidant Activity, In Silico Molecular Docking, and ADMET Prediction Study
    Zelelew, Demis
    Endale, Milkyas
    Melaku, Yadessa
    Demissie, Taye B.
    Ombito, Japheth O.
    Eswaramoorthy, Rajalakshmanan
    JOURNAL OF CHEMISTRY, 2022, 2022
  • [36] Synthesis, molecular docking and molecular dynamics simulations, drug-likeness studies, ADMET prediction and biological evaluation of novel pyrazole-carboxamides bearing sulfonamide moiety as potent carbonic anhydrase inhibitors
    Yetek, Irfan
    Mert, Samet
    Tunca, Ekrem
    Bayrakdar, Alpaslan
    Kasimogullari, Rahmi
    MOLECULAR DIVERSITY, 2025, 29 (02) : 1207 - 1227
  • [37] Bifunctional neuraminidase inhibitory and simultaneously anti-Mycoplasma pneumoniae of flavan-3-ols and flavanones: Combined molecular docking, virtual screening, ADMET, and synthesis prediction
    Pham-Khanh, Nguyen-Huan
    Ha, Thi-Kim-Quy
    Duong, Khe-Vinh
    JOURNAL OF KING SAUD UNIVERSITY SCIENCE, 2024, 36 (07)
  • [38] Design, one-pot synthesis, in silico ADMET prediction and molecular docking of novel triazolyl thiadiazine and thiazole derivatives with evaluation of antimicrobial, antioxidant and antibiofilm inhibition activity
    Khidre, Rizk E.
    Sabry, Eman
    El-Sayed, Ahmed F.
    Sediek, Ashraf A.
    JOURNAL OF THE IRANIAN CHEMICAL SOCIETY, 2023, 20 (12) : 2923 - 2947
  • [39] Design, one-pot synthesis, in silico ADMET prediction and molecular docking of novel triazolyl thiadiazine and thiazole derivatives with evaluation of antimicrobial, antioxidant and antibiofilm inhibition activity
    Rizk E. Khidre
    Eman Sabry
    Ahmed F. El-Sayed
    Ashraf A. Sediek
    Journal of the Iranian Chemical Society, 2023, 20 : 2923 - 2947
  • [40] Conventional versus microwave assisted synthesis, molecular docking and enzyme inhibitory activities of new 3,4,5-trisubstituted-1,2,4-triazole analogues
    Virk, Naeem Akhtar
    Aziz-ur-Rehman
    Abbasi, Muhammad Athar
    Siddiqui, Sabahat Zahra
    Rashid, Umer
    Iqbal, Javed
    Saleem, Muhammad
    Ashraf, Muhammad
    Shahid, Wardah
    Shah, Syed Adnan Ali
    PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2018, 31 (04) : 1501 - 1510
12345