Tubulointerstitial lesions in IgA nephropathy and localization of hepatocyte growth factor

被引：4
|
作者：
Fidirkin A. [1 ]
Neimark A. [2 ]
Nepomnyashchikh D. [3 ]
Olovyannikov S. [1 ]
Tanashkin S. [1 ]
Sapoznikova L. [1 ]
机构：
[1] Department of Pathology, Altai Medical University, Barnaul
[2] Department of Urology, Altai Medical University, Barnaul
[3] Division of Experimental Pathology, Inst. of Pathol. and Pathomorphology, Novosibirsk
来源：
International Urology and Nephrology | 1999年 / 31卷 / 4期
关键词：
Public Health; Microscopy; Growth Factor; Epithelial Cell; Light Microscopy;
D O I：
10.1023/A:1007183832512
中图分类号：
学科分类号：
摘要：
To investigate the relationship between localization of hepatocyte growth factor (HGF) and tubulointerstitial lesions (TILs) in the cortical area of renal biopsy specimens, a clinicopathological study was performed in 55 patients with IgA nephropathy. HGF was detected by an enzyme-antibody method and TILs were assessed semiquantitatively by light microscopy. HGF was observed mainly on epithelial cells in the tubules, but not in the glomeruli. Fourteen patients had biopsies that were positive for HGF. There was a correlation between HGF positivity and histological damage, the TIL grade, and several clinical parameters determined at biopsy. Thus, HGF is related to TILs in IgA nephropathy and may be a factor in the exacerbation of this disease.
引用
收藏
页码：557 / 562
页数：5
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