Tubulointerstitial lesions in IgA nephropathy and localization of hepatocyte growth factor

被引：4
|
作者：
Fidirkin A. [1 ]
Neimark A. [2 ]
Nepomnyashchikh D. [3 ]
Olovyannikov S. [1 ]
Tanashkin S. [1 ]
Sapoznikova L. [1 ]
机构：
[1] Department of Pathology, Altai Medical University, Barnaul
[2] Department of Urology, Altai Medical University, Barnaul
[3] Division of Experimental Pathology, Inst. of Pathol. and Pathomorphology, Novosibirsk
来源：
International Urology and Nephrology | 1999年 / 31卷 / 4期
关键词：
Public Health; Microscopy; Growth Factor; Epithelial Cell; Light Microscopy;
D O I：
10.1023/A:1007183832512
中图分类号：
学科分类号：
摘要：
To investigate the relationship between localization of hepatocyte growth factor (HGF) and tubulointerstitial lesions (TILs) in the cortical area of renal biopsy specimens, a clinicopathological study was performed in 55 patients with IgA nephropathy. HGF was detected by an enzyme-antibody method and TILs were assessed semiquantitatively by light microscopy. HGF was observed mainly on epithelial cells in the tubules, but not in the glomeruli. Fourteen patients had biopsies that were positive for HGF. There was a correlation between HGF positivity and histological damage, the TIL grade, and several clinical parameters determined at biopsy. Thus, HGF is related to TILs in IgA nephropathy and may be a factor in the exacerbation of this disease.
引用
收藏
页码：557 / 562
页数：5
相关论文
共 50 条
  • [21] Immunohistochemical localization of latent transforming growth factor-beta binding protein in IgA nephropathy
    Wada, T
    Hamakawa, S
    Hori, Y
    Kaname, S
    Shimizu, S
    Kurokawa, K
    Katoh, T
    KIDNEY INTERNATIONAL, 1997, : S182 - S184
  • [22] Hepatocyte growth factor on CsA-induced nephropathy
    Yoshimura, R
    Ksai, S
    Sugimura, K
    Ohyama, A
    Nakatani, T
    Yamamoto, K
    Kishimoto, T
    RETRANSPLANTATION, 1997, 29 : 328 - 328
  • [23] TUBULOINTERSTITIAL NEPHRITIS IN A PATIENT WITH EOSINOPHILIC FASCIITIS AND IGA NEPHROPATHY
    TAKEDA, SI
    TAKAZAKURA, E
    FUKUI, Y
    NEPHRON, 1995, 69 (03): : 314 - 317
  • [24] EPIDERMAL GROWTH-FACTOR RECEPTORS IN IGA NEPHROPATHY
    ROYCHAUDHURY, P
    GRABOWSKI, P
    HAITES, NE
    MCLEOD, AM
    POWER, DA
    KIDNEY INTERNATIONAL, 1992, 41 (03) : 699 - 700
  • [25] HEPATOCYTE HANDLING OF SOLUBLE IGA AGGREGATES IN EXPERIMENTAL IGA NEPHROPATHY
    GONZALEZ, E
    SANCHO, J
    GONZALEZ, J
    BLASCO, R
    BARAT, A
    HOYO, RG
    LOZANO, L
    EGIDO, J
    HERNANDO, L
    KIDNEY INTERNATIONAL, 1985, 28 (03) : 586 - 586
  • [26] The role of IgA in proximal tubular cell activation and tubulointerstitial scarring in IgA nephropathy
    Cheung, Chee Kay
    Molyneux, Karen
    Boyd, Joanna
    Baines, Richard
    Brunskill, Nigel
    Barratt, Jonathan
    LANCET, 2014, 383 : 34 - 34
  • [27] Complement factor H variants are associated with microangiopathy lesions in IgA nephropathy
    Hou, Wanyin
    Shi, Sufang
    Zhou, Xujie
    Wang, Suxia
    Cai, Qingqing
    Chen, Pei
    Liu, Lijun
    Zhu, Li
    Lv, Jicheng
    Zhang, Hong
    INTERNATIONAL IMMUNOPHARMACOLOGY, 2022, 112
  • [28] HYPERURICAEMIA WAS A STRONG PREDICTIVE FACTOR OF RENAL ARTERIOLAR LESIONS IN IGA NEPHROPATHY
    Qiu, Qiang
    Chen, Xiangmei
    Wei, Ribao
    Wu, Di
    Cai, Guangyan
    Liu, Shuwen
    Tang, Li
    NEPHROLOGY, 2005, 10 : A44 - A44
  • [29] Study of hepatocyte growth factor in cyclosporine-induced nephropathy
    Kasai, S
    Yoshimura, R
    Sugimura, K
    Ohyama, A
    Harimoto, K
    Kishimoto, T
    Yoshimura, N
    TRANSPLANTATION PROCEEDINGS, 1997, 29 (03) : 1724 - 1725
  • [30] Tubulointerstitial Macrophages in IgA Nephropathy Assessed by Digital Image Analysis
    Genitsch, Vera
    Soares, Maria Fernanda
    Roberts, Ian
    MODERN PATHOLOGY, 2018, 31 : 612 - 612
12345