CDK9 inhibitors downregulate DKK1 expression to suppress the metastatic potential of HCC cells

被引:0
|
作者
Mijin Park
Jin Hwa Cho
Byul Moon
Jeong-Hoon Kim
Jung-Ae Kim
机构
[1] Aging Convergence Research Center,Department of Bioscience
[2] Korea Research Institute of Bioscience and Biotechnology,Graduate School of New Drug Discovery and Development
[3] University of Science and Technology,undefined
[4] Disease Target Structure Research Center,undefined
[5] Korea Research Institute of Bioscience and Biotechnology,undefined
[6] Chungnam National University,undefined
来源
Genes & Genomics | 2023年 / 45卷
关键词
Liver cancer; DKK1; CDK9 inhibitor; Migration; Invasion;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:285 / 293
页数:8
相关论文
共 50 条
  • [41] Discovery of new imidazole[1,2-a] pyridine derivatives as CDK9 inhibitors: design, synthesis and biological evaluation
    Sun, Zihan
    Sun, Shijun
    Li, Xiayu
    Li, Xiang
    Li, Chuang
    Tang, Li
    Cheng, Maosheng
    Liu, Yang
    RSC MEDICINAL CHEMISTRY, 2025,
  • [42] Role of cdk9 in the Optimization of Expression of the Genes Regulated by ICP22 of Herpes Simplex Virus 1
    Durand, Lizette Olga
    Roizman, Bernard
    JOURNAL OF VIROLOGY, 2008, 82 (21) : 10591 - 10599
  • [43] Inhibitors Targeting CDK9 Show High Efficacy against Osimertinib and AMG510 Resistant Lung Adenocarcinoma Cells
    Padmanabhan, Jaya
    Saha, Biswarup
    Powell, Chase
    Mo, Qianxing
    Perez, Bradford A.
    Chellappan, Srikumar
    CANCERS, 2021, 13 (15)
  • [44] c-Myc transforms human mammary epithelial cells through repression of the Wnt inhibitors DKK1 and SFRP1
    Cowling, Victoria H.
    D'Cruz, Celina M.
    Chodosh, Lewis A.
    Cole, Michael D.
    MOLECULAR AND CELLULAR BIOLOGY, 2007, 27 (14) : 5135 - 5146
  • [45] C/EBPβ regulates human immunodeficiency virus 1 gene expression through its association with cdk9
    Mameli, Giuseppe
    Deshmane, Satish L.
    Ghafouri, Mohammad
    Cui, Jianqi
    Simbiri, Kenneth
    Khalili, Kamel
    Mukerjee, Ruma
    Dolei, Antonina
    Amini, Shohreh
    Sawaya, Bassel E.
    JOURNAL OF GENERAL VIROLOGY, 2007, 88 : 631 - 640
  • [46] Regulatory functions of Cdk9 and of cyclin T1 in HIV Tat transactivation pathway gene expression
    Romano, G
    Kasten, M
    De Falco, G
    Micheli, P
    Khalili, K
    Giordano, A
    JOURNAL OF CELLULAR BIOCHEMISTRY, 1999, 75 (03) : 357 - 368
  • [47] Uncovering potential CDK9 inhibitors from natural compound databases through docking-based virtual screening and MD simulations
    Singh, Pooja
    Kumar, Vikas
    Jung, Tae Sung
    Lee, Jeong Sang
    Lee, Keun Woo
    Hong, Jong Chan
    JOURNAL OF MOLECULAR MODELING, 2024, 30 (08)
  • [48] CDK inhibitors suppress apoptosis induced by chemicals and by excessive expression of a cell death gene, reaper, in Drosophila cells
    Nagano, M
    Ui-Tei, K
    Suzuki, H
    Piao, ZF
    Miyata, Y
    APOPTOSIS, 2000, 5 (06) : 543 - 550
  • [49] OTUD1 promotes hypertensive kidney fibrosis and injury by deubiquitinating CDK9 in renal epithelial cells
    Meng-yang Wang
    Tian-xiang Yu
    Qin-yan Wang
    Xue Han
    Xiang Hu
    Shi-ju Ye
    Xiao-hong Long
    Yi Wang
    Hong Zhu
    Wu Luo
    Guang Liang
    Acta Pharmacologica Sinica, 2024, 45 : 765 - 776
  • [50] CDK inhibitors suppress apoptosis induced by chemicals and by excessive expression of a cell death gene, reaper, in Drosophila cells
    M. Nagano
    K. Ui-Tei
    H. Suzuki
    Zheng-fu Piao
    Y. Miyata
    Apoptosis, 2000, 5 : 543 - 550