CDK9 inhibitors downregulate DKK1 expression to suppress the metastatic potential of HCC cells

被引：0
|
作者：
Mijin Park
Jin Hwa Cho
Byul Moon
Jeong-Hoon Kim
Jung-Ae Kim
机构：
[1] Aging Convergence Research Center,Department of Bioscience
[2] Korea Research Institute of Bioscience and Biotechnology,Graduate School of New Drug Discovery and Development
[3] University of Science and Technology,undefined
[4] Disease Target Structure Research Center,undefined
[5] Korea Research Institute of Bioscience and Biotechnology,undefined
[6] Chungnam National University,undefined
来源：
Genes & Genomics | 2023年 / 45卷
关键词：
Liver cancer; DKK1; CDK9 inhibitor; Migration; Invasion;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
页码：285 / 293
页数：8
相关论文
共 50 条
  • [31] DKK1 expression is suppressed by miR-9 during induced dopaminergic differentiation of human trabecular meshwork mesenchymal stem cells
    Mirfazeli, Elham Sadat
    Arefian, Ehsan
    Nadri, Samad
    Valojerdi, Rezvan Rezazadeh
    Kehtari, Mousa
    Zeynali, Bahman
    NEUROSCIENCE LETTERS, 2019, 707
  • [32] CDK9 inhibitors modulate the transcriptional landscape of colorectal cancer to suppress MAPK signaling and synergizes with BRAF inhibitors to treat BRAF-mutant colorectal cancer
    Kuang, Chaoyuan
    Wei, Ning
    Mohammadi, Mahshid
    Bhat, Muzaffer A.
    Li, Terence
    Patil, Priyanka
    Wiltz, Othon
    Huang, Renee
    Ooka, Kohtaro
    Quintal, Melanie
    Chu, Edward
    CANCER RESEARCH, 2024, 84 (06)
  • [33] The CUL5 ubiquitin ligase complex mediates resistance to CDK9 and MCL1 inhibitors in lung cancer cells
    Kabir, Shaheen
    Cidado, Justin
    Andersen, Courtney
    Dick, Cortni
    Lin, Pei-Chun
    Mitros, Therese
    Ma, Hong
    Baik, Seung Hyun
    Belmonte, Matthew A.
    Drew, Lisa
    Corn, Jacob E.
    ELIFE, 2019, 8
  • [34] Novel tacrine derivatives as potential CDK9 inhibitors with low cholinesterase inhibitory properties: design, synthesis, and biological evaluation
    Liu, Wenwu
    Huang, Yaoguang
    Wu, Limeng
    Liu, Wenjie
    Jiang, Xiaowen
    Xu, Zihua
    Zhao, Qingchun
    NEW JOURNAL OF CHEMISTRY, 2022, 46 (40) : 19342 - 19356
  • [35] Cdk9/Cyclin T1 expression during normal lymphoid differentiation and malignant transformation
    不详
    VIRCHOWS ARCHIV, 2005, 447 (02) : 271 - 272
  • [36] Expression of CDK9 in endometrial cancer tissues and its effect on the proliferation of HEC-1B
    Yang, Wen
    Liu, Shaoyan
    Luo, Qiuping
    Tan, Xuexian
    OPEN LIFE SCIENCES, 2021, 16 (01): : 1341 - 1346
  • [37] CDK9/CYCLIN T1 expression during normal lymphoid differentiation and malignant transformation
    Bellan, C
    De Falco, G
    Lazzi, S
    Micheli, R
    Vicidomini, S
    Schürfeld, K
    Amato, T
    Palumbo, A
    Bagella, L
    Sabattini, E
    Bartolommei, S
    Hummel, M
    Pileri, S
    Tosi, P
    Leoncini, L
    Giordano, A
    JOURNAL OF PATHOLOGY, 2004, 203 (04): : 946 - 952
  • [38] CDK/CK1 inhibitors roscovitine and CR8 downregulate amplified MYCN in neuroblastoma cells
    C Delehouzé
    K Godl
    N Loaëc
    C Bruyère
    N Desban
    N Oumata
    H Galons
    T I Roumeliotis
    E G Giannopoulou
    J Grenet
    D Twitchell
    J Lahti
    N Mouchet
    M-D Galibert
    S D Garbis
    L Meijer
    Oncogene, 2014, 33 : 5675 - 5687
  • [39] CDK/CK1 inhibitors roscovitine and CR8 downregulate amplified MYCN in neuroblastoma cells
    Delehouze, C.
    Godl, K.
    Loaec, N.
    Bruyere, C.
    Desban, N.
    Oumata, N.
    Galons, H.
    Roumeliotis, T. I.
    Giannopoulou, E. G.
    Grenet, J.
    Twitchell, D.
    Lahti, J.
    Mouchet, N.
    Galibert, M-D
    Garbis, S. D.
    Meijer, L.
    ONCOGENE, 2014, 33 (50) : 5675 - 5687
  • [40] Tumor cells induce neural DKK1 expression to promote MDSC infiltration and subsequent T cell suppression
    Liu, Ruoyan
    Shi, Xiaotian
    Qian, Shuangshuang
    Sun, Zhonghao
    Dai, Hao
    Wu, Yongwei
    Cao, Shihui
    Luo, Jingtao
    Zhang, Ze
    CELLULAR SIGNALLING, 2025, 127
12345