High-resolution structure of infectious prion protein: the final frontier

被引：0
|
作者：
Rodrigo Diaz-Espinoza
Claudio Soto
机构：
[1] Mitchell Center for Alzheimer's Disease and Related Brain Disorders,Department of Neurology
[2] University of Texas Medical School,undefined
来源：
Nature Structural & Molecular Biology | 2012年 / 19卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
PrPSc, the infective agent for transmissible spongiform encephalopathies, is the misfolded form of the prion protein that can template the conversion of the native fold of the protein (PrPC). The high-resolution structure of PrPSc remains elusive. This review presents recent progress in the area and existing structural models, in addition to discussing the challenges ahead.
引用
收藏
页码：370 / 377
页数：7
相关论文
共 50 条
  • [31] A high-resolution probe of protein folding
    Sagle, LB
    Zimmermann, J
    Dawson, PE
    Romesberg, FE
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (11) : 3384 - 3385
  • [32] High-resolution design of a protein loop
    Hu, Xiaozhen
    Wang, Huanchen
    Ke, Hengming
    Kuhlman, Brian
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (45) : 17668 - 17673
  • [33] The most infectious prion protein particles
    Silveira, JR
    Raymond, GJ
    Hughson, AG
    Race, RE
    Sim, VL
    Hayes, SF
    Caughey, B
    NATURE, 2005, 437 (7056) : 257 - 261
  • [34] Reconstruction of Infectious Prion Protein in vitro
    Sano, Kazunori
    Atarashi, Ryuichiro
    Nishida, Noriyuki
    PRION, 2011, 5 : 80 - 80
  • [35] Plasminogen detects infectious prion protein
    不详
    CHEMICAL & ENGINEERING NEWS, 2000, 78 (48) : 21 - 21
  • [36] The most infectious prion protein particles
    Jay R. Silveira
    Gregory J. Raymond
    Andrew G. Hughson
    Richard E. Race
    Valerie L. Sim
    Stanley F. Hayes
    Byron Caughey
    Nature, 2005, 437 : 257 - 261
  • [37] A receptor for infectious and cellular prion protein
    Martins, VR
    BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, 1999, 32 (07) : 853 - 859
  • [38] HIGH-RESOLUTION ACOUSTIC STRUCTURE OF FISH
    NASH, RDM
    SUN, Y
    CLAY, CS
    JOURNAL DU CONSEIL, 1987, 44 (01): : 23 - 31
  • [39] High-resolution structure of a β-peptide bundle
    Daniels, Douglas S.
    Petersson, E. James
    Qiu, Jade X.
    Schepartz, Alanna
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2007, 129 (06) : 1532 - +
  • [40] VIRUS STRUCTURE - HIGH-RESOLUTION PERSPECTIVES
    HARRISON, SC
    ADVANCES IN VIRUS RESEARCH, 1983, 28 : 175 - 240
12345