High-resolution structure of infectious prion protein: the final frontier

被引：0
|
作者：
Rodrigo Diaz-Espinoza
Claudio Soto
机构：
[1] Mitchell Center for Alzheimer's Disease and Related Brain Disorders,Department of Neurology
[2] University of Texas Medical School,undefined
来源：
Nature Structural & Molecular Biology | 2012年 / 19卷
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D O I：
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摘要：
PrPSc, the infective agent for transmissible spongiform encephalopathies, is the misfolded form of the prion protein that can template the conversion of the native fold of the protein (PrPC). The high-resolution structure of PrPSc remains elusive. This review presents recent progress in the area and existing structural models, in addition to discussing the challenges ahead.
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页码：370 / 377
页数：7
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