Axonal prion protein is required for peripheral myelin maintenance

被引：0

作者：

Juliane Bremer

Frank Baumann

Cinzia Tiberi

Carsten Wessig

Heike Fischer

Petra Schwarz

Andrew D Steele

Klaus V Toyka

Klaus-Armin Nave

Joachim Weis

Adriano Aguzzi

机构：

[1] Institute of Neuropathology,Department of Neurology

[2] University Hospital of Zürich,Division of Biology

[3] University of Würzburg,Department of Neurogenetics

[4] California Institute of Technology,undefined

[5] Max-Planck Institute of Experimental Medicine,undefined

[6] Institute of Neuropathology,undefined

[7] Medical Faculty,undefined

[8] Rheinisch-Westfälische Technische Hochschule (RWTH,undefined

[9] ) University Aachen,undefined

来源：

Nature Neuroscience | 2010年 / 13卷

关键词：

D O I：

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学科分类号：

摘要：

The signals ensuring maintenance of the myelin sheath on peripheral nerves are distinct from those instructing myelination and are largely unknown. Here, the authors report that neuronal expression and regulated proteolysis of the prion protein are essential for myelin maintenance.

引用

页码：310 / 318

页数：8

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