Synthesis, structure and cytotoxic activity of cobalt(II), nickel(II) and copper(II) chloride complexes with acetamidrazones

被引：0

作者：

Gustavo Ponticelli

M. Teresa Cocco

Cenzo Congiu

Valentina Onnis

Sandra Ianelli

Francesco Cossu

机构：

[1] Universita' degli Studi di Cagliari,Dipartimento di Chimica Inorganica ed Analitica

[2] Cittadella di Monserrato,Dipartimento di Tossicologia

[3] Universita' degli Studi di Cagliari,Dipartimento di Chimica Generale ed Inorganica, Chimica Analitica, Chimica Fisica

[4] Universita' di Parma,Istituto di Radiologia, Facoltà di Medicina

[5] Universita' degli Studi di Cagliari,undefined

来源：

Transition Metal Chemistry | 2001年 / 26卷

关键词：

Copper; Nickel; Cobalt; Adenocarcinoma; Cytotoxic Activity;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

CoII, NiII and CuII chloride complexes with acetamidrazone derivatives (L1)–(L8) have been prepared, by reacting the corresponding metal chloride with the ligand in a 1:2 ratio, and characterised by chemical analysis and physical measurements. The ligand behaviour and the geometry have been assigned on the basis of i.r. spectroscopy, electronic reflectance spectra and molar conductivity values and only, where possible, the geometry has been confirmed as octahedral by X-ray structure determination. Complexes cytotoxicity on a human cellular line of adenocarcinoma was also tested. Three of the complexes present a weak cytotoxicity in vitro.

引用

页码：24 / 27

页数：3

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