Acute Myeloid Leukemia with Multilineage Dysplasia in Children

被引：0
|
作者：
Souichi Adachi
Atsushi Manabe
Masue Imaizumi
Takashi Taga
Akio Tawa
Masahito Tsurusawa
Akira Kikuchi
Atsuko Masunaga
Masahiro Tsuchida
Tatsutoshi Nakahata
机构：
[1] Graduate School of Medicine,Department of Pediatrics
[2] Kyoto University,Department of Pediatrics
[3] St. Luke’s International Hospital,Department of Hematology and Oncology
[4] Miyagi Children’s Hospital,Department of Pediatrics
[5] Shiga University of Medical Science,Department of Pediatrics
[6] National Hospital Organization Osaka National Hospital,Department of Pediatrics
[7] Aichi Medical University,Division of Hematology/Oncology
[8] Saitama Children’s Medical Center,Department of Surgical Pathology
[9] Showa University Fujigaoka Hospital,Department of Pediatrics
[10] Ibaraki Children’s Hospital,undefined
来源：
International Journal of Hematology | 2007年 / 86卷
关键词：
AML with multilineage dysplasia; Children; Retrospective analysis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
We retrospectively surveyed pediatric acute myeloid leukemia (AML) patients with multilineage dysplasia treated with the AML 99 and the Children's Cancer and Leukemia Study Group (CCLSG) AML 9805 protocols. We found only 9 AML patients (2.6%) with multilineage dysplasia among the 341 patients with newly diagnosed de novo AML. Eight of the 9 patients obtained complete remission (CR) following the intensive AML-oriented treatments. Three of 7 patients who underwent stem cell transplantation were alive in CR for more than 4 years, and the 2 patients treated only with chemotherapy were alive in CR for more than 30 months. We did not identify any particular chromosomal abnormalities or differentiation according to the French-American-British classification in these 9 patients. No reports have described AML with multilineage dysplasia in children, and the incidence of the disease is expected to be very low. We plan to conduct a prospective pathologic review to select cases with this disease entity in the next Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG) AML-05 protocol.
引用
收藏
页码：358 / 363
页数：5
相关论文
共 50 条
  • [21] Prognostic impact of acute myeloid leukemia classification - Importance of detection of recurring cytogenetic abnormalities and multilineage dysplasia on survival
    Arber, DA
    Stein, AS
    Carter, NH
    Ikle, D
    Forman, SJ
    Slovak, ML
    AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 2003, 119 (05) : 672 - 680
  • [22] Clonal "devolution" in a case of essential thrombocythemia with transformation from refractory cytopenia with multilineage dysplasia to acute myeloid leukemia
    Nath, Shriram V.
    Westerman, David
    Campbell, Lynda J.
    Seymour, John F.
    LEUKEMIA & LYMPHOMA, 2006, 47 (06) : 1160 - 1162
  • [23] AZACITIDINE IMPROVES THE T-CELL REPERTOIRE IN PATIENTS WITH MYELODYPSLASTIC SYNDROMES AND ACUTE MYELOID LEUKEMIA WITH MULTILINEAGE DYSPLASIA
    Fozza, C.
    Corda, G.
    Barraqueddu, F.
    Virdis, P.
    Contini, S.
    Isoni, A.
    Dore, F.
    Angelucci, E.
    Longinotti, M.
    HAEMATOLOGICA, 2015, 100 : 102 - 102
  • [24] AZACITIDINE IMPROVES THE T-CELL REPERTOIRE IN PATIENTS WITH MYELODYSPLASTIC SYNDROMES AND ACUTE MYELOID LEUKEMIA WITH MULTILINEAGE DYSPLASIA
    Fozza, C.
    Corda, G.
    Barraqueddu, F.
    Virdis, P.
    Contini, S.
    Isoni, A.
    Dore, F.
    Angelucci, E.
    Longinotti, M.
    HAEMATOLOGICA, 2015, 100 : 237 - 237
  • [25] Fludarabine, Cytarabine and G-CSF (FLAG) as treatment of de novo acute myeloid leukemia with multilineage dysplasia.
    Ferrara, F
    Palmieri, S
    Schiavone, EM
    Annunziata, M
    Copia, C
    Annunziata, S
    Gianfaldoni, G
    Leoni, F
    BLOOD, 2001, 98 (11) : 212B - 212B
  • [26] Acute myeloid leukemia with myelodysplasia-related changes diagnosed with multilineage dysplasia alone demonstrates a superior clinical outcome
    Jiang, Gina
    Capo-Chichi, Jose-Mario
    Liu, Aijun
    Atenafu, Eshetu G.
    Guo, Robert
    Tierens, Ann
    Minden, Mark D.
    Chang, Hong
    HUMAN PATHOLOGY, 2020, 104 : 117 - 126
  • [27] Bone marrow VEGFC expression is associated with multilineage dysplasia and several prognostic markers in adult acute myeloid leukemia, but not with survival
    Guillem, Vicent
    Calabuig, Marisa
    Brunet, Salut
    Esteve, Jordi
    Escoda, Lourdes
    Gallardo, David
    Ribera, Josep-Maria
    Queipo de Llano, Maria Paz
    Arnan, Montserrat
    Pedro, Carme
    Luz Amigo, Maria
    Marti-Tutusaus, Josep M.
    Garcia-Guinon, Antoni
    Bargay, Joan
    Sampol, Antonia
    Salamero, Olga
    Font, Llorenc
    Talarn, Carme
    Hoyos, Montserrat
    Diaz-Beya, Marina
    Garrido, Ana
    Navarro, Blanca
    Nomdedeu, Josep
    Sierra, Jordi
    Tormo, Mar
    LEUKEMIA & LYMPHOMA, 2018, 59 (10) : 2383 - 2393
  • [28] The Genotype Consisting of Complex Karyotype and TP53 Gene Mutation Is Specific to Acute Myeloid Leukemia with Multilineage Dysplasia
    Ishikawa, Yuichi
    Kiyoi, Hitoshi
    Tsujimura, Akane
    Miyazaki, Yasushi
    Tomonaga, Masao
    Kuriyama, Kazutaka
    Miyawaki, Shuichi
    Naoe, Tomoki
    BLOOD, 2008, 112 (11) : 870 - 870
  • [29] Complete cytogenetic and molecular response to treatment with imatinib mesylate for Philadelphia chromosome positive acute myeloid leukemia with multilineage dysplasia
    Ueda, Kyoji
    Horiike, Shigeo
    Zen, Keika
    Misawa, Shinichi
    Taniwaki, Masafumi
    LEUKEMIA & LYMPHOMA, 2006, 47 (09) : 1967 - 1969
  • [30] Marrow fibrosis as a risk factor for posttransplantation outcome in patients with advanced myelodysplastic syndrome or acute myeloid leukemia with multilineage dysplasia
    Scott, Bart L.
    Storer, Barry E.
    Greene, Joanne E.
    Hackman, Robert C.
    Appelbaum, Frederick R.
    Deeg, H. Joachim
    BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2007, 13 (03) : 345 - 354
12345