Bone marrow VEGFC expression is associated with multilineage dysplasia and several prognostic markers in adult acute myeloid leukemia, but not with survival

被引：0

作者：

Guillem, Vicent ^{[1
]}

Calabuig, Marisa ^{[1
]}

Brunet, Salut ^{[2
,3
]}

Esteve, Jordi ^{[4
]}

Escoda, Lourdes ^{[5
]}

Gallardo, David ^{[6
]}

Ribera, Josep-Maria ^{[7
]}

Queipo de Llano, Maria Paz ^{[8
]}

Arnan, Montserrat ^{[9
]}

Pedro, Carme ^{[10
]}

Luz Amigo, Maria ^{[11
]}

Marti-Tutusaus, Josep M. ^{[12
]}

Garcia-Guinon, Antoni ^{[13
]}

Bargay, Joan ^{[14
]}

Sampol, Antonia ^{[15
]}

Salamero, Olga ^{[16
]}

Font, Llorenc ^{[17
]}

Talarn, Carme ^{[4
]}

Hoyos, Montserrat ^{[2
,3
]}

Diaz-Beya, Marina ^{[4
]}

Garrido, Ana ^{[2
,3
]}

Navarro, Blanca ^{[1
]}

Nomdedeu, Josep ^{[2
,3
]}

Sierra, Jordi ^{[2
,3
]}

Tormo, Mar ^{[1
]}

机构：

[1] Hosp Clin Univ INCLIVA Biomed Res Inst, Dept Hematol & Med Oncol, Valencia, Spain

[2] Univ Autonoma Barcelona, Dept Hematol, Hosp St Pau, IIB St Pau Leukemia Res Inst, Barcelona, Spain

[3] Univ Autonoma Barcelona, Dept Hematol, Hosp St Pau, Jose Carreras Leukemia Res Inst, Barcelona, Spain

[4] IDIBAPS, Hosp Clin, Dept Hematol, Barcelona, Spain

[5] Hosp Univ Joan XIII, Dept Hematol, Tarragona, Spain

[6] Hosp Josep Trueta, IDIBGI Fdn, ICO Girona, Dept Hematol, Girona, Spain

[7] Univ Autonoma Barcelona, Josep Carreras Leukemia Res Inst, Hosp Germans Trias & Pujol, Dept Hematol,ICO Badalona, Badalona, Spain

[8] Hosp Virgen Victoria, Dept Hematol, Malaga, Spain

[9] Hosp Duran i Reynals, Dept Hematol, ICO, Barcelona, Spain

[10] Hosp del Mar, Dept Hematol, Parc Salut Mar, Barcelona, Spain

[11] Hosp Morales Meseguer, Dept Hematol, Murcia, Spain

[12] Hosp Univ Mutua Terrassa, Terrassa, Spain

[13] Hosp Univ Arnau Villanova, Dept Hematol, Lleida, Spain

[14] Hosp Son Llatzer, Dept Hematol, Mallorca, Spain

[15] Univ Hosp Son Espases, Inst IDISPA, Dept Hematol, Palma De Mallorca, Spain

[16] Hosp Valle De Hebron, Dept Hematol, Barcelona, Spain

[17] Hosp Verge Cinta, Dept Hematol, Tortosa, Spain

来源：

LEUKEMIA & LYMPHOMA | 2018年 / 59卷 / 10期

关键词：

Acute myeloid leukemia; VEGFC expression; VEGF signaling; FLT1; KDR; NRP1; GROWTH-FACTOR VEGF; GENE-EXPRESSION; CELL GROWTH; ANGIOGENESIS; MIGRATION; PROLIFERATION; DIAGNOSIS; DISEASE; FLT-1; PCR;

D O I：

10.1080/10428194.2017.1422858

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Vascular endothelial growth factor C (VEGFC) stimulates leukemia cell proliferation and survival, and promotes angiogenesis. We studied VEGFC expression in bone marrow samples from 353 adult acute myeloid leukemia (AML) patients and its relationship with several clinical, cytogenetic, and molecular variables. We also studied the expression of 84 genes involved in VEGF signaling in 24 patients. We found that VEGFC expression was higher in AML patients with myelodysplasia-related changes (AML-MRC) than in patients with non-AML-MRC. We also found an association between VEGFC expression and the patient cytogenetic risk group, with those with a worse prognosis having higher VEGFC expression levels. No correlation was observed between VEGFC expression and survival or complete remission. VEGFC expression strongly correlated with expression of the VEGF receptors FLT1, KDR, and NRP1. Thus, in this series, VEGFC expression was increased in AML-MRC and in subgroups with a poorer prognosis, but has no impact on survival.

引用

页码：2383 / 2393

页数：11

共 50 条

[1] Bone marrow trephine findings in acute myeloid leukaemia with multilineage dysplasia
Ngo, Nyethane
Summary, Irvin A. Lampert
Naresh, Kikkeri N.
BRITISH JOURNAL OF HAEMATOLOGY, 2008, 140 (03) : 279 - 286
[2] Prognostic impact of acute myeloid leukemia classification - Importance of detection of recurring cytogenetic abnormalities and multilineage dysplasia on survival
Arber, DA
Stein, AS
Carter, NH
Ikle, D
Forman, SJ
Slovak, ML
AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 2003, 119 (05) : 672 - 680
[3] Syndrome of inappropriate antidiuretic hormone secretion associated with acute myeloid leukemia with multilineage dysplasia
Nakayama, Shoko
Yokote, Taiji
Kobayashi, Kichinosuke
Hirata, Yuji
Akioka, Toshikazu
Miyoshi, Takuji
Takubo, Takayuki
Tsuji, Motomu
Hanafusa, Toshiaki
ENDOCRINE, 2009, 35 (03) : 290 - 292
[4] Multilineage Dysplasia as Assessed by Immunophenotype in Acute Myeloid Leukemia: A Prognostic Tool in a Genetically Undefined Category
Mannelli, Francesco
Bencini, Sara
Piccini, Matteo
Gianfaldoni, Giacomo
Bonetti, Maria Ida
Peruzzi, Benedetta
Caporale, Roberto
Scappini, Barbara
Pancani, Fabiana
Ponziani, Vanessa
Signori, Leonardo
Zizza, Michela
Annunziato, Francesco
Bosi, Alberto
CANCERS, 2020, 12 (11) : 1 - 15
[5] MULTILINEAGE DYSPLASIA AS ASSESSED BY IMMUNOPHENOTYPE IN ACUTE MYELOID LEUKEMIA: A PROGNOSTIC TOOL IN GENETICALLY UNDEFINED CATEGORY
Mannelli, F.
Bencini, S.
Bonetti, M.
Pancani, F.
Ponziani, V.
Piccini, M.
Cutini, I.
Di Lorenzo, S.
Gianfaldoni, G.
Scappini, B.
Bosi, A.
HAEMATOLOGICA, 2017, 102 : 70 - 70
[6] Syndrome of inappropriate antidiuretic hormone secretion associated with acute myeloid leukemia with multilineage dysplasia
Shoko Nakayama
Taiji Yokote
Kichinosuke Kobayashi
Yuji Hirata
Toshikazu Akioka
Takuji Miyoshi
Takayuki Takubo
Motomu Tsuji
Toshiaki Hanafusa
Endocrine, 2009, 35 : 290 - 292
[7] Prognostic significance of the frequencies of bone marrow lymphocyte subsets in adult acute myeloid leukemia at diagnosis
Sun, Kai
Wang, Jun
Wang, Ya-Zhe
Shi, Zong-Yan
Chang, Yan
Yuan, Xiao-Ying
Liu, Yan-Rong
Jiang, Hao
Jiang, Qian
Huang, Xiao-Jun
Qin, Ya-Zhen
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY, 2024, 46 (02) : 294 - 302
[8] High VEGFC expression is associated with unique gene expression profiles and predicts adverse prognosis in pediatric and adult acute myeloid leukemia
de Jonge, Hendrik J. M.
Valk, Peter J. M.
Veeger, Nic J. G. M.
ter Elst, Arja
den Boer, Monique L.
Cloos, Jacqueline
de Haas, Valerie
van den Heuvel-Eibrink, Marry M.
Kaspers, Gertjan J. L.
Zwaan, Christian M.
Kamps, Willem A.
Lowenberg, Bob
de Bont, Eveline S. J. M.
BLOOD, 2010, 116 (10) : 1747 - 1754
[9] Gene expression differences between adult acute myeloid leukemia (AML) with multilineage dysplasia and AML, not otherwise categorized of the WHO classification
Arber, DA
Ma, LN
MODERN PATHOLOGY, 2005, 18 : 221A - 222A
[10] Gene expression differences between adult acute myeloid leukemia (AML) with multilineage dysplasia and AML, not otherwise categorized of the WHO classification
Arber, DA
Ma, LN
LABORATORY INVESTIGATION, 2005, 85 : 221A - 222A

← 1 2 3 4 5 →