Spectrophotometric Determination of Metoclopramide in Pharmaceutical Preparations

被引：0
|
作者：
J. Shah
M. Rasul Jan
M. Azam Khan
S. Amin
机构：
[1] University of Peshawar,Department of Chemistry
[2] N.W.F.P.,undefined
来源：
Journal of Analytical Chemistry | 2005年 / 60卷
关键词：
Sodium; Analytical Chemistry; Hydroxide; Acidity; Nitrite;
D O I：
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中图分类号：
学科分类号：
摘要：
A simple and rapid spectrophotometric method for the determination of metoclopramide is described. The method is based upon simple diazotization reactions with nitrite and aniline as the coupling reagent. The absorbance was measured at 410 nm. The method was optimized for acidity, the amount of reagents required, and the amount of sodium hydroxide. The range of linearity was 0.5–12.0 µg/mL. The method was successfully applied to the determination of metoclopramide in pharmaceutical preparations without any interference from common excipients.
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页码：633 / 635
页数：2
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