Radiolabeled novel peptide for imaging somatostatin-receptor expressing tumor: synthesis and radiobiological evaluation

被引:0
|
作者
Kakali De
Asoke Behera
Indranil Banerjee
Bharat Sarkar
Santanu Ganguly
Mridula Misra
机构
[1] Council of Scientific and Industrial Research (CSIR)-Indian Institute of Chemical Biology (IICB),Department of Infectious Diseases and Immunology (Nuclear Medicine Division)
[2] Variable Energy Cyclotron Centre,Regional Radiation Medicine Centre
来源
Journal of Radioanalytical and Nuclear Chemistry | 2014年 / 301卷
关键词
Somatostatin receptor; HYNIC; Octreotate; Tc; C6 tumor;
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中图分类号
学科分类号
摘要
The aim of this study was to synthesis, a radiolabeled (99mTc) new somatostatin-analogue 6-hydrazinopyridine-3-carboxylic-acid (HYNIC)-Asn3-octreotate (99mTc-HYNIC-AATE), and to evaluate as a candidate for imaging somatostatin-receptor (SSTR)-positive tumors and also compare it with 99mTc-HYNIC-Tyr3-octreotide (99mTc-HYNIC-TOC). Synthesis was performed by Fmoc-solid-phase strategy and 99mTc labeled by SnCl2. Biodistribution and imaging properties of new radiopeptide were also studied in C6 tumor bearing rat. Radiolabeling was performed at high specific activities and it showed high binding-affinity for SSTR2. In biodistribution, radiopeptides have showed high and receptor-specific uptake in the SSTR2 positive organs, tumor with rapid renal excretion from non-target tissues. These results demonstrated that 99mTc-HYNIC-AATE is a new specific radioligand for scintigraphy of somatostatin-receptor-positive tumors.
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页码:847 / 861
页数:14
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