Cell-fate determination by ubiquitin-dependent regulation of translation

被引：0
|
作者：
Achim Werner
Shintaro Iwasaki
Colleen A. McGourty
Sofia Medina-Ruiz
Nia Teerikorpi
Indro Fedrigo
Nicholas T. Ingolia
Michael Rape
机构：
[1] Howard Hughes Medical Institute,Department of Molecular and Cell Biology
[2] University of California,undefined
[3] University of California,undefined
来源：
Nature | 2015年 / 525卷
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摘要：
This study shows that a vertebrate-specific ubiquitin ligase modulates neural crest specification in Xenopus development and human embryonic stem-cell differentiation; a proteomics approach reveals that the CUL3KBTBD8 ligase modulates translation by targeting the modulators of ribosomes production NOLC1 and its paralogue TCOF1, which is mutated in a neural-crest-associated syndrome.
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页码：523 / 527
页数：4
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