Synthesis of N,N′-di(1-adamantyl)bispidin-9-ones

被引：0
|
作者：
A. I. Kuznetsov
I. M. Senan
R. T. Alasadi
N. M. Abdulnabi
T. M. Serova
机构：
[1] Moscow Technological University,Institute of Physiologically Active Compounds
[2] University of Sana,undefined
[3] University of Kerbala,undefined
[4] University of Al-Mustansiria,undefined
[5] Russian Academy of Sciences,undefined
来源：
Russian Chemical Bulletin | 2018年 / 67卷
关键词：
adamantan-1-amine; amantadine; 3,7-diazabicyclo[3.3.1]nonane; bispidine; 1,5-disubstituted 3,7-di(1-adamantyl)-3,7-diazabicyclo[3.3.1]nonan-9-ones; 1,5-disubstituted 3,7-di(1-adamantyl)-3,7-diazabicyclo[3.3.1]nonan-9-ols; 3,7-di(1-adamantyl)-1-[(1-adamantylamino) methyl]-5-methyl-3,7-diazabicyclo[3.3.1]nonan-9-one; 1,5-bis[(1-adamantylamino) methyl]-3,7-di(1-adamantyl)-3,7-diazabicyclo[3.3.1]nonan-9-one; 1,5-disubstituted ; ,; ′-di(1-adamantyl)bispidin-9-ones; ,; ′-di(1-adamantyl)-1-[(1-adamantylamino)methyl]-5-methylbispidin-9-one; ,; ′-di(1-adamantyl)-1,5-bis[(1-adamantylamino)methyl]bispidin-9-one.;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The condensation product of adamantan-1-amine with formaldehyde, 1,3,5-tri(1-adamantyl)-1,3,5-triazacyclohexane, was treated with three different types of ketones: symmetric (RCH2)2CO, nonsymmetric RCH2COCH3, and acetone to obtain 1,5-R-N,N′-di(1-adamantyl) bispidin-9-ones, N,N′-di(1-adamantyl)-1-[(1-adamantylamino)methyl]-5-methylbispidin-9-one, and N,N′-di(1-adamantyl)-1,5-bis[(1-adamantylamino)methyl]bispidin-9-one. 1,5-R-N,N′-Di(1-adamantyl)bispidin-9-ones were reduced with sodium borohydride to 1,5-R-N,N′-di(1-adamantyl)bispidin-9-ols.
引用
收藏
页码：1110 / 1113
页数：3
相关论文
共 50 条
  • [1] Synthesis of N,N-di(1-adamantyl)bispidin-9-ones
    Kuznetsov, A. I.
    Senan, I. M.
    Alasadi, R. T.
    Abdulnabi, N. M.
    Serova, T. M.
    [J]. RUSSIAN CHEMICAL BULLETIN, 2018, 67 (06) : 1110 - 1113
  • [2] Synthesis of N,N'-di(tert-butyl)bispidin-9-ones
    Kuznetsov, A. I.
    Senan, I. M.
    Serova, T. M.
    [J]. RUSSIAN CHEMICAL BULLETIN, 2012, 61 (02) : 308 - 312
  • [3] Synthesis of N,N′-di(tert-butyl)bispidin-9-ones
    A. I. Kuznetsov
    I. M. Senan
    T. M. Serova
    [J]. Russian Chemical Bulletin, 2012, 61 : 308 - 312
  • [4] SIMPLE SYNTHESIS OF N-(1-ADAMANTYL)CARBAMATES
    KLIMOCHKIN, YN
    MOISEEV, IK
    [J]. ZHURNAL ORGANICHESKOI KHIMII, 1991, 27 (08): : 1795 - 1796
  • [5] SYNTHESIS AND STRUCTURE OF N,N'-BIS-(1-ADAMANTYL) FORMAMIDINE
    KREUTZBERGER, A
    SCHRODER.HH
    [J]. TETRAHEDRON LETTERS, 1971, (39) : 3635 - +
  • [6] DI(1-ADAMANTYL)PHOSPHINES
    LAVROVA, EA
    KOIDAN, GN
    MARCHENKO, AP
    PINCHUK, AM
    [J]. ZHURNAL OBSHCHEI KHIMII, 1994, 64 (09): : 1556 - 1557
  • [7] REACTIONS OF THERMALLY GENERATED 1-ADAMANTYL AND DI(1-ADAMANTYL)KETYL RADICALS IN TOLUENE
    LOMAS, JS
    FAIN, D
    BRIAND, S
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 1990, 55 (03): : 1052 - 1058
  • [8] PSYCHOTROPIC PROPERTIES OF N-(1-ADAMANTYL)-N'-SUBSTITUTED PIPERAZINES
    GERMANE, SK
    POLIS, YY
    KARINYA, LY
    [J]. KHIMIKO-FARMATSEVTICHESKII ZHURNAL, 1977, 11 (03): : 66 - 70
  • [9] A new route to N-(1-adamantyl)nicotinamide
    Sokolenko, VA
    Svirskaya, NM
    Pavlenko, NI
    [J]. RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2006, 76 (02) : 331 - 332
  • [10] (1-ADAMANTYL)DICHLOROPHOSPHINE IN SYNTHESIS OF (1-ADAMANTYL)DIBROMO(DIIODO)PHOSPHINES
    MIROSHNICHENKO, VV
    YURCHENKO, RI
    FESHCHENKO, NG
    [J]. ZHURNAL OBSHCHEI KHIMII, 1993, 63 (01): : 231 - 232
12345