Synthesis of N,N′-di(1-adamantyl)bispidin-9-ones

被引：0
|
作者：
A. I. Kuznetsov
I. M. Senan
R. T. Alasadi
N. M. Abdulnabi
T. M. Serova
机构：
[1] Moscow Technological University,Institute of Physiologically Active Compounds
[2] University of Sana,undefined
[3] University of Kerbala,undefined
[4] University of Al-Mustansiria,undefined
[5] Russian Academy of Sciences,undefined
来源：
Russian Chemical Bulletin | 2018年 / 67卷
关键词：
adamantan-1-amine; amantadine; 3,7-diazabicyclo[3.3.1]nonane; bispidine; 1,5-disubstituted 3,7-di(1-adamantyl)-3,7-diazabicyclo[3.3.1]nonan-9-ones; 1,5-disubstituted 3,7-di(1-adamantyl)-3,7-diazabicyclo[3.3.1]nonan-9-ols; 3,7-di(1-adamantyl)-1-[(1-adamantylamino) methyl]-5-methyl-3,7-diazabicyclo[3.3.1]nonan-9-one; 1,5-bis[(1-adamantylamino) methyl]-3,7-di(1-adamantyl)-3,7-diazabicyclo[3.3.1]nonan-9-one; 1,5-disubstituted ; ,; ′-di(1-adamantyl)bispidin-9-ones; ,; ′-di(1-adamantyl)-1-[(1-adamantylamino)methyl]-5-methylbispidin-9-one; ,; ′-di(1-adamantyl)-1,5-bis[(1-adamantylamino)methyl]bispidin-9-one.;
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学科分类号：
摘要：
The condensation product of adamantan-1-amine with formaldehyde, 1,3,5-tri(1-adamantyl)-1,3,5-triazacyclohexane, was treated with three different types of ketones: symmetric (RCH2)2CO, nonsymmetric RCH2COCH3, and acetone to obtain 1,5-R-N,N′-di(1-adamantyl) bispidin-9-ones, N,N′-di(1-adamantyl)-1-[(1-adamantylamino)methyl]-5-methylbispidin-9-one, and N,N′-di(1-adamantyl)-1,5-bis[(1-adamantylamino)methyl]bispidin-9-one. 1,5-R-N,N′-Di(1-adamantyl)bispidin-9-ones were reduced with sodium borohydride to 1,5-R-N,N′-di(1-adamantyl)bispidin-9-ols.
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页码：1110 / 1113
页数：3
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