Evidence for monomeric actin function in INO80 chromatin remodeling

被引：0
|
作者：
Prabodh Kapoor
Mingming Chen
Duane David Winkler
Karolin Luger
Xuetong Shen
机构：
[1] The University of Texas MD Anderson Cancer Center,Department of Molecular Carcinogenesis
[2] Howard Hughes Medical Institute,Department of Biochemistry and Molecular Biology
[3] Colorado State University,undefined
来源：
Nature Structural & Molecular Biology | 2013年 / 20卷
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摘要：
While the cytoplasmic functions of actin are well established, its nuclear roles remain poorly understood. Genetic and biochemical analyses of the nuclear actin-containing yeast INO80 chromatin-remodeling complex now demonstrate that actin functions as a monomer in the nucleus and contributes to INO80 remodeling activity, suggesting a mechanism fundamentally different from that of cytoplasmic actin.
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页码：426 / 432
页数：6
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