INO80 subfamily of chromatin remodeling complexes

被引:82
|
作者
Bao, Yunhe [1 ]
Shen, Xuetong [1 ]
机构
[1] Univ Texas, MD Anderson Canc Ctr, Dept Carcinogenesis, Sci Pk Res Div, Smithville, TX 78957 USA
关键词
INO80; SWR1; ATP-dependent chromatin remodeling; DNA repair; histone variant; actin; Arps; Rvb1; Rvb2; H2AZ; H2AX;
D O I
10.1016/j.mrfmmm.2006.10.006
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
ATP-dependent chromatin remodeling complexes contain ATPases of the Swi/Snf superfamily and alter DNA accessibility of chromatin in an ATP-dependent manner. Recently characterized INO80 and SWR1 complexes belong to a subfamily of these chromatin remodelers and are characterized by a split ATPase domain in the core ATPase subunit and the presence of Rvb proteins. INO80 and SWR1 complexes are evolutionarily conserved from yeast to human and have been implicated in transcription regulation, as well as DNA repair. The individual components, assembly patterns, and molecular mechanisms of the INO80 class of chromatin remodeling complexes are discussed in this review. (C) 2007 Elsevier B.V. All rights reserved.
引用
收藏
页码:18 / 29
页数:12
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