Preparation of optical active aliphatic α-amino acid from fatty acid: synthesis of l-norvaline and d-norvaline

被引：0
|
作者：
Chao Qian
Ling Gong
Xin Zhi Chen
机构：
[1] Zhejiang University,College of Materials Science and Chemical Engineering
来源：
Research on Chemical Intermediates | 2009年 / 35卷
关键词：
Valeric acid; -Norvaline; -Norvaline; Resolution; α-Amino acid;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A new synthesis of l-norvaline is described. Using valeric acid as the raw material, α-brominevaleryl chloride was achieved by acyl chlorination and α-position bromination in one-pot with the yield of 84.7%. The yields of the following ammoniation of α-brominevaleryl chloride and resolution of dl-norvaline were 88.7% and 26.7%, respectively. d-Norvaline was also obtained in a similar method from the waste resolution solution. Other optical active amino acids, valine, α-aminobutyric acid and alanine were also synthesized in similar ways.
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页码：117 / 121
页数：4
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