Enzymatic Synthesis of Aliphatic Primary ω-Amino Alcohols from ω-Amino Fatty Acids by Carboxylic Acid Reductase

被引：0

作者：

Sarak, Sharad ^{[1
]}

Jeon, Hyunwoo ^{[1
]}

Patil, Mahesh D. ^{[1
]}

Khobragade, Taresh P. ^{[1
]}

Pagar, Amol D. ^{[1
]}

Sung, Sihyong ^{[1
]}

Yoo, Hee-Wang ^{[2
]}

Kim, Byung-Gee ^{[2
,3
]}

Yoon, Sung Ho ^{[1
]}

Yun, Hyungdon ^{[1
]}

机构：

[1] Department of Systems Biotechnology, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul,050-29, Korea, Republic of

[2] Bioengineering Institute, Seoul National University, Seoul,08826, Korea, Republic of

[3] School of Chemical and Biological Engineering, Seoul National University, Seoul,08826, Korea, Republic of

来源：

Catalysis Letters | 2020年 / 150卷 / 11期

关键词：

Escherichia coli;

D O I：

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中图分类号：

学科分类号：

摘要：

Medium to long chain aliphatic amino alcohols have numerous applications in polymer-based industries. We herein report a biocatalytic reduction of amino fatty acids into corresponding amino alcohols using carboxylic acid reductase and E coli endogenous aldehyde reductases. Interestingly, employing this reaction in tandem with minimizing the hurdle of substrate insolubility, the biocatalysts successfully produced 5.76 mM 12-amino-1-dodecanol from 10 mM of corresponding 12-amino-dodecanoic acid. Finally, up to 9.17 mM of 8-amino-1-octanol was obtained in 24 h on a preparative scale reaction of 50 mM substrate. Graphic Abstract: [Figure not available: see fulltext.] © 2020, Springer Science+Business Media, LLC, part of Springer Nature.

引用

页码：3079 / 3085

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