Loss-of-function genetic diseases and the concept of pharmaceutical targets

被引：0
|
作者：
Ryan R. Brinkmann
Marie-Pierre Dubé
Guy A. Rouleau
Andrew C. Orr
Mark E. Samuels
机构：
来源：
Nature Reviews Genetics | 2007年 / 8卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
页码：404 / 404
相关论文
共 50 条
  • [31] Laminin: loss-of-function studies
    Yao, Yao
    CELLULAR AND MOLECULAR LIFE SCIENCES, 2017, 74 (06) : 1095 - 1115
  • [32] Loss-of-function found in droves
    Nature, 2012, 482 (7386) : 443 - 443
  • [33] Laminin: loss-of-function studies
    Yao Yao
    Cellular and Molecular Life Sciences, 2017, 74 : 1095 - 1115
  • [34] The two faces of protein misfolding: gain- and loss-of-function in neurodegenerative diseases
    Winklhofer, Konstanze F.
    Tatzelt, Joerg
    Haass, Christian
    EMBO JOURNAL, 2008, 27 (02): : 336 - 349
  • [35] Loss-of-function screening identifies therapeutic targets for triple negative breast cancer (TNBC)
    Bauer, Joshua A.
    Lehmann, Brian D.
    Glick, Gloria
    Cortez, David
    Lee, Ethan
    Pietenpol, Jennifer A.
    CANCER RESEARCH, 2011, 71
  • [36] Identification of Rare Loss-of-Function Genetic Variation Regulating Body Fat Distribution
    Koprulu, Mine
    Zhao, Yajie
    Wheeler, Eleanor
    Dong, Liang
    Rocha, Nuno
    Li, Chen
    Griffin, John D.
    Patel, Satish
    Van de Streek, Marcel
    Glastonbury, Craig A.
    Stewart, Isobel D.
    Day, Felix R.
    Luan, Jian'an
    Bowker, Nicholas
    Wittemans, Laura B. L.
    Kerrison, Nicola D.
    Cai, Lina
    Lucarelli, Debora M. E.
    Barroso, Ines
    McCarthy, Mark, I
    Scott, Robert A.
    Saudek, Vladimir
    Small, Kerrin S.
    Wareham, Nicholas J.
    Semple, Robert K.
    Perry, John R. B.
    O'Rahilly, Stephen
    Lotta, Luca A.
    Langenberg, Claudia
    Savage, David B.
    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2022, 107 (04): : 1065 - 1077
  • [37] Genetic regulation of branching morphogenesis: Lessons learned from loss-of-function phenotypes
    Hu, MC
    Rosenblum, ND
    PEDIATRIC RESEARCH, 2003, 54 (04) : 433 - 438
  • [38] Apoc2 loss-of-function zebrafish mutant as a genetic model of hyperlipidemia
    Liu, Chao
    Gates, Keith P.
    Fang, Longhou
    Amar, Marcelo J.
    Schneider, Dina A.
    Geng, Honglian
    Huang, Wei
    Kim, Jungsu
    Pattison, Jennifer
    Zhang, Jian
    Witztum, Joseph L.
    Remaley, Alan T.
    Duc Dong, P.
    Miller, Yury I.
    DISEASE MODELS & MECHANISMS, 2015, 8 (08) : 989 - 998
  • [39] Genetic Regulation of Branching Morphogenesis: Lessons Learned from Loss-of-Function Phenotypes
    Ming Chang Hu
    Norman D Rosenblum
    Pediatric Research, 2003, 54 : 433 - 438
  • [40] Loss-of-function variants in the Finnish population
    Orli Bahcall
    Nature Genetics, 2014, 46 (9) : 933 - 933
12345