Loss-of-function genetic diseases and the concept of pharmaceutical targets

被引:0
|
作者
Ryan R. Brinkmann
Marie-Pierre Dubé
Guy A. Rouleau
Andrew C. Orr
Mark E. Samuels
机构
来源
Nature Reviews Genetics | 2007年 / 8卷
关键词
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:404 / 404
相关论文
共 50 条
  • [21] Loss-of-Function Genetic Screens to Find Genes Regulating Cell Responses and Identify Potential Drug Targets.
    Diehl, P.
    Tedesco, D.
    Bonneau, K.
    Makhanov, M.
    Deng, D.
    Hyder, K.
    Sun, P.
    Chenchik, A. A.
    MOLECULAR BIOLOGY OF THE CELL, 2014, 25
  • [22] Genetic Load of Loss-of-Function Polymorphic Variants in Great Apes
    de Valles-Ibanez, Guillem
    Hernandez-Rodriguez, Jessica
    Prado-Martinez, Javier
    Luisi, Pierre
    Marques-Bonet, Tomas
    Casals, Ferran
    GENOME BIOLOGY AND EVOLUTION, 2016, 8 (03): : 871 - 877
  • [23] Drought adaptation in Arabidopsis thaliana by extensive genetic loss-of-function
    Monroe, J. Grey
    Powell, Tyler
    Price, Nicholas
    Mullen, Jack L.
    Howard, Anne
    Evans, Kyle
    Lovell, John T.
    McKay, John K.
    ELIFE, 2018, 7
  • [24] Loss-of-function variants
    Orli Bahcall
    Nature Genetics, 2012, 44 (4) : 368 - 368
  • [25] Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease
    Nielsen, Jonas B.
    Rom, Oren
    Surakka, Ida
    Graham, Sarah E.
    Zhou, Wei
    Roychowdhury, Tanmoy
    Fritsche, Lars G.
    Taliun, Sarah A. Gagliano
    Sidore, Carlo
    Liu, Yuhao
    Gabrielsen, Maiken E.
    Skogholt, Anne Heidi
    Wolford, Brooke
    Overton, William
    Zhao, Ying
    Chen, Jin
    Zhang, He
    Hornsby, Whitney E.
    Acheampong, Akua
    Grooms, Austen
    Schaefer, Amanda
    Zajac, Gregory J. M.
    Villacorta, Luis
    Zhang, Jifeng
    Brumpton, Ben
    Loset, Mari
    Rai, Vivek
    Lundegaard, Pia R.
    Olesen, Morten S.
    Taylor, Kent D.
    Palmer, Nicholette D.
    Chen, Yii-Der
    Choi, Seung H.
    Lubitz, Steven A.
    Ellinor, Patrick T.
    Barnes, Kathleen C.
    Daya, Michelle
    Rafaels, Nicholas
    Weiss, Scott T.
    Lasky-Su, Jessica
    Tracy, Russell P.
    Vasan, Ramachandran S.
    Cupples, L. Adrienne
    Mathias, Rasika A.
    Yanek, Lisa R.
    Becker, Lewis C.
    Peyser, Patricia A.
    Bielak, Lawrence F.
    Smith, Jennifer A.
    Aslibekyan, Stella
    NATURE COMMUNICATIONS, 2020, 11 (01)
  • [26] Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease
    Jonas B. Nielsen
    Oren Rom
    Ida Surakka
    Sarah E. Graham
    Wei Zhou
    Tanmoy Roychowdhury
    Lars G. Fritsche
    Sarah A. Gagliano Taliun
    Carlo Sidore
    Yuhao Liu
    Maiken E. Gabrielsen
    Anne Heidi Skogholt
    Brooke Wolford
    William Overton
    Ying Zhao
    Jin Chen
    He Zhang
    Whitney E. Hornsby
    Akua Acheampong
    Austen Grooms
    Amanda Schaefer
    Gregory J. M. Zajac
    Luis Villacorta
    Jifeng Zhang
    Ben Brumpton
    Mari Løset
    Vivek Rai
    Pia R. Lundegaard
    Morten S. Olesen
    Kent D. Taylor
    Nicholette D. Palmer
    Yii-Der Chen
    Seung H. Choi
    Steven A. Lubitz
    Patrick T. Ellinor
    Kathleen C. Barnes
    Michelle Daya
    Nicholas Rafaels
    Scott T. Weiss
    Jessica Lasky-Su
    Russell P. Tracy
    Ramachandran S. Vasan
    L. Adrienne Cupples
    Rasika A. Mathias
    Lisa R. Yanek
    Lewis C. Becker
    Patricia A. Peyser
    Lawrence F. Bielak
    Jennifer A. Smith
    Stella Aslibekyan
    Nature Communications, 11
  • [27] Loss-of-function genetic screens as a tool to improve the diagnosis and treatment of cancer
    J Mullenders
    R Bernards
    Oncogene, 2009, 28 : 4409 - 4420
  • [28] Predicting Loss-of-Function Impact of Genetic Mutations: A Machine Learning Approach
    Kaur, Arshmeet
    Sarmadi, Morteza
    ADVANCES IN ARTIFICIAL INTELLIGENCE AND MACHINE LEARNING, 2024, 4 (01): : 2091 - 2102
  • [29] Loss-of-function genetic screens as a tool to improve the diagnosis and treatment of cancer
    Mullenders, J.
    Bernards, R.
    ONCOGENE, 2009, 28 (50) : 4409 - 4420
  • [30] Loss-of-function mutations in RET
    Chakravarti, A
    JOURNAL OF INTERNAL MEDICINE, 2004, 255 (06) : 705 - 705