The druggability of SH2 domains unmasked

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作者：
Oliver Hantschel
机构：
[1] Philipps-University of Marburg,Institute of Physiological Chemistry
来源：
Nature Chemical Biology | 2024年 / 20卷
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摘要：
Developing inhibitors for SH2 domains is challenging due to their shallow pockets and highly charged ligands. Structure-guided drug design has enabled the discovery of a cell-permeable covalent inhibitor of the SOCS2 SH2 domain, a key regulator of cytokine signaling pathways.
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页码：271 / 272
页数：1
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