The druggability of SH2 domains unmasked

被引：0
|
作者：
Oliver Hantschel
机构：
[1] Philipps-University of Marburg,Institute of Physiological Chemistry
来源：
Nature Chemical Biology | 2024年 / 20卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Developing inhibitors for SH2 domains is challenging due to their shallow pockets and highly charged ligands. Structure-guided drug design has enabled the discovery of a cell-permeable covalent inhibitor of the SOCS2 SH2 domain, a key regulator of cytokine signaling pathways.
引用
收藏
页码：271 / 272
页数：1
相关论文
共 50 条
  • [31] SIGNAL-TRANSDUCTION - ZAPPING TANDEM SH2 DOMAINS
    WEISS, A
    NATURE, 1995, 377 (6544) : 17 - 18
  • [32] SPECIFICITY OF PROTEIN-TYROSINE KINASES AND SH2 DOMAINS
    SONGYANG, Z
    CARRAWAY, KL
    ECK, MJ
    HARRISON, SC
    MAYE, BJ
    FELDMAN, RA
    CANTLEY, LC
    JOURNAL OF CELLULAR BIOCHEMISTRY, 1995, : 43 - 43
  • [33] Insulin receptor binding proteins with SH2 domains.
    Nishi, M
    Frantz, JD
    Trub, T
    GiorgettiPeraldi, S
    Lee, JS
    Shoelson, S
    DIABETES, 1997, 46 : 1092 - 1092
  • [34] CRYSTAL-STRUCTURES OF PEPTIDE COMPLEXES OF SH2 DOMAINS
    KURIYAN, J
    LEE, CH
    KOMINOS, D
    WAKSMAN, G
    WU, XD
    KRISHNA, TSR
    COWBURN, D
    SHOELSON, SE
    FASEB JOURNAL, 1994, 8 (07): : A1377 - A1377
  • [35] Superbinder SH2 Domains Act as Antagonists of Cell Signaling
    Kaneko, Tomonori
    Huang, Haiming
    Cao, Xuan
    Li, Xing
    Li, Chengjun
    Voss, Courtney
    Sidhu, Sachdev S.
    Li, Shawn S. C.
    SCIENCE SIGNALING, 2012, 5 (243)
  • [36] MEASUREMENT OF THE BINDING OF TYROSYL PHOSPHOPEPTIDES TO SH2 DOMAINS - A REAPPRAISAL
    LADBURY, JE
    LEMMON, MA
    ZHOU, M
    GREEN, J
    BOTFIELD, MC
    SCHLESSINGER, J
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (08) : 3199 - 3203
  • [37] DIRECT DETERMINATION OF THE SEQUENCE RECOGNITION REQUIREMENTS OF THE SH2 DOMAINS OF SH-PTP2
    HUYER, G
    LI, ZM
    ADAM, M
    HUCKLE, WR
    RAMACHANDRAN, C
    BIOCHEMISTRY, 1995, 34 (03) : 1040 - 1049
  • [38] Specificity and regulation of phosphotyrosine signaling through SH2 domains
    Marasco, Michelangelo
    Carlomagno, Teresa
    JOURNAL OF STRUCTURAL BIOLOGY-X, 2020, 4
  • [39] SH2 domains in plants imply new signalling scenarios
    Williams, JG
    Zvelebil, M
    TRENDS IN PLANT SCIENCE, 2004, 9 (04) : 161 - 163
  • [40] Alternative modes of binding of proteins with tandem SH2 domains
    O'Brien, R
    Rugman, P
    Renzoni, D
    Layton, M
    Handa, R
    Hilyard, K
    Waterfield, MD
    Driscoll, PC
    Ladbury, JE
    PROTEIN SCIENCE, 2000, 9 (03) : 570 - 579
12345