Chimeric provirus of bovine leukemia virus/SMAD family member 3 in cattle with enzootic bovine leukosis

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作者：
Naganori Nao
Tomohiro Okagawa
Naomi Nojiri
Satoru Konnai
Honami Shimakura
Misono Tominaga
Hazuka Yoshida-Furihata
Eri Nishiyama
Takahiro Matsudaira
Naoya Maekawa
Shiro Murata
Masamichi Muramatsu
Kazuhiko Ohashi
Masumichi Saito
机构：
[1] Hokkaido University,Division of International Research Promotion, International Institute for Zoonosis Control
[2] Hokkaido University,One Health Research Center
[3] Hokkaido University,Institute for Vaccine Research and Development (IVReD)
[4] Hokkaido University,Department of Advanced Pharmaceutics, Faculty of Veterinary Medicine
[5] National Institute of Infectious Diseases,Center for Emergency Preparedness and Response
[6] Hokkaido University,Department of Disease Control, Faculty of Veterinary Medicine
[7] FASMAC Co.,Biotechnological Research Support Division
[8] Ltd,Department of Virology II
[9] National Institute of Infectious Diseases,undefined
来源：
Archives of Virology | 2024年 / 169卷
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摘要：
Bovine leukemia virus (BLV) is a member of the family Retroviridae that causes enzootic bovine leukemia (EBL). However, the association between BLV infection and EBL development remains unclear. In this study, we identified a BLV/SMAD3 chimeric provirus within CC2D2A intron 30 in monoclonal expanded malignant cells from a cow with EBL. The chimeric provirus harbored a spliced SMAD3 sequence composed of exons 3–9, encoding the short isoform protein, and the BLV-SMAD3 chimeric transcript was detectable in cattle with EBL. This is the first report of a BLV chimeric provirus that might be involved in EBL tumorigenesis.
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