Chimeric provirus of bovine leukemia virus/SMAD family member 3 in cattle with enzootic bovine leukosis

被引：0

作者：

Naganori Nao

Tomohiro Okagawa

Naomi Nojiri

Satoru Konnai

Honami Shimakura

Misono Tominaga

Hazuka Yoshida-Furihata

Eri Nishiyama

Takahiro Matsudaira

Naoya Maekawa

Shiro Murata

Masamichi Muramatsu

Kazuhiko Ohashi

Masumichi Saito

机构：

[1] Hokkaido University,Division of International Research Promotion, International Institute for Zoonosis Control

[2] Hokkaido University,One Health Research Center

[3] Hokkaido University,Institute for Vaccine Research and Development (IVReD)

[4] Hokkaido University,Department of Advanced Pharmaceutics, Faculty of Veterinary Medicine

[5] National Institute of Infectious Diseases,Center for Emergency Preparedness and Response

[6] Hokkaido University,Department of Disease Control, Faculty of Veterinary Medicine

[7] FASMAC Co.,Biotechnological Research Support Division

[8] Ltd,Department of Virology II

[9] National Institute of Infectious Diseases,undefined

来源：

Archives of Virology | 2024年 / 169卷

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摘要：

Bovine leukemia virus (BLV) is a member of the family Retroviridae that causes enzootic bovine leukemia (EBL). However, the association between BLV infection and EBL development remains unclear. In this study, we identified a BLV/SMAD3 chimeric provirus within CC2D2A intron 30 in monoclonal expanded malignant cells from a cow with EBL. The chimeric provirus harbored a spliced SMAD3 sequence composed of exons 3–9, encoding the short isoform protein, and the BLV-SMAD3 chimeric transcript was detectable in cattle with EBL. This is the first report of a BLV chimeric provirus that might be involved in EBL tumorigenesis.

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[31] Delayed-onset enzootic bovine leukosis possibly caused by superinfection with bovine leukemia virus mutated in the pol gene
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[32] EXPERIMENTAL AND NATURAL INFECTION WITH THE ENZOOTIC BOVINE LEUKOSIS VIRUS (BLV)
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[33] Enzootic bovine leukosis: Experimental induction with two sources of virus
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[37] Provirus variants of the bovine leukemia virus and their relation to the serological status of naturally infected cattle
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[38] Provirus variants of bovine leukemia virus in naturally infected cattle from Argentina and Japan
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[39] ENZOOTIC BOVINE LEUKOSIS EPIDEMIOLOGY RELATED TO BIOCHEMICAL STUDIES ON BLV VIRUS
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[40] THE EFFECTS OF ENZOOTIC BOVINE LEUKOSIS ON THE ECONOMICS OF CATTLE PRODUCTION IN COSTA-RICA
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