Synthesis and evaluation of curcumin analogues as cytotoxic agents

被引：0
|
作者：
Ahmed A. Fadda
Farid A. Badria
Khaled M. El-Attar
机构：
[1] Mansoura University,Chemistry Department, Faculty of Science
[2] Mansoura University,Pharmacognosy Department, Faculty of Pharmacy
来源：
Medicinal Chemistry Research | 2010年 / 19卷
关键词：
Hydroxycurcuminoids; Synthesis; Ehrlich ascites in vitro; Antitumor;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Seventeen curcumin analogues were prepared and evaluated for in vitro and in vivo cytotoxicity against an Ehrlich ascites carcinoma (EAC). In vitro results revealed that compounds 10, 7, and 12 were the most potent analogues against EAC respectively. However, in vivo evaluation of compound 10 proved its capability to normalize the blood picture compared with 5-fluorouracil, a well-known anticancer drug.
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页码：413 / 430
页数：17
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