Synthesis and evaluation of curcumin analogues as potential thioredoxin reductase inhibitors

被引：68

作者：

Qiu, Xu ^{[1
]}

Liu, Zhong ^{[1
]}

Shao, Wei-Yan ^{[1
]}

Liu, Xing ^{[2
]}

Jing, Da-Ping ^{[1
]}

Yu, Yan-Jun ^{[1
]}

An, Lin-Kun ^{[1
]}

Huang, Shi-Liang ^{[1
]}

Bu, Xian-Zhang ^{[1
]}

Huang, Zhi-Shu ^{[1
]}

Gu, Lian-Quan ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510275, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, Zhongshan Sch Med, Guangzhou 510080, Guangdong, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2008年 / 16卷 / 17期

关键词：

curcumin derivatives; TrxR inhibitor; furan moiety;

D O I：

10.1016/j.bmc.2008.07.054

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Series of curcumin derivatives were synthesized; the inhibitory activities on thioredoxin reductase (TrxR) of all analogues were evaluated by DTNB assay in vitro. It is found that most of the analogues can inhibit TrxR in the low micromolar range; Structure-activity relationship analysis reveals that analogues with furan moiety have excellent inhibitory effect on TrxR in an irreversible manner, indicating that the furan moiety may serve as a possible pharmacophore during the interaction of curcumin analogues with TrxR. The effect of selected curcuminoids on growth of different TrxR overexpressed cancer cell lines was also investigated and discussed. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：8035 / 8041

页数：7

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