Does neuronal expression of GDNF effectively protect dopaminergic neurons in a rat model of Parkinson's disease?

被引：0

作者：

N A Do Thi

P Saillour

L Ferrero

T Paunio

J Mallet

机构：

[1] Laboratoire de Genetique Moleculaire de la Neurotransmission et des Processus Neurodegeneratifs,Department of Molecular Medicine

[2] CNRS,undefined

[3] UMR 7091,undefined

[4] Bat. CERVI,undefined

[5] Hopital Pitie-Salpetriere,undefined

[6] Gencell SAS,undefined

[7] Vitry sur Seine,undefined

[8] Biomedicum,undefined

来源：

Gene Therapy | 2007年 / 14卷

关键词：

adenoviral vector; Parkinson's disease; Glial cell line-derived neurotrophic factor; NSE promoter;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The transfer of the Glial cell line-derived neurotrophic factor (GDNF) gene to the central nervous system by a recombinant adenoviral vector (Ad) was studied. We constructed the adenovirus vector Ad-NSE-GDNF from which the E1, E3/E4 regions of Ad5 have been deleted and in which the GDNF gene was under the control of a neuron-specific enolase (NSE) promoter. The vector was injected into the striatum of a rat model of Parkinson's disease. We found that (i) the NSE promoter can restrict transgene expression in neurons; (ii) Ad-NSE-GDNF significantly protected dopaminergic (DA) neurons in the substantia nigra (SN) but did not reverse the impairments of amphetamine-induced rotational behavior in lesioned rats.

引用

页码：441 / 450

页数：9

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